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Mossberg N, Andersen O, Nordin M, et al. Leukocyte oxygen radical production determines disease severity in the recurrent Guillain-Barré syndrome. J Inflamm (Lond). 2010;7:40doi: 10.1186/1476-9255-7-40.
Mossberg, N., Andersen, O., Nordin, M., Nilsson, S., Svedhem, A., Bergström, T., Hellstrand, K., & Movitz, C. (2010). Leukocyte oxygen radical production determines disease severity in the recurrent Guillain-Barré syndrome. Journal of inflammation (London, England), 740. https://doi.org/10.1186/1476-9255-7-40
Mossberg, Natalia, et al. "Leukocyte oxygen radical production determines disease severity in the recurrent Guillain-Barré syndrome." Journal of inflammation (London, England) vol. 7 (2010): 40. doi: https://doi.org/10.1186/1476-9255-7-40
Mossberg N, Andersen O, Nordin M, Nilsson S, Svedhem A, Bergström T, Hellstrand K, Movitz C. Leukocyte oxygen radical production determines disease severity in the recurrent Guillain-Barré syndrome. J Inflamm (Lond). 2010 Aug 08;7:40. doi: 10.1186/1476-9255-7-40. PMID: 20691112; PMCID: PMC2924308.
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J Inflamm (Lond). 2010 Aug 08;7:40. doi: 10.1186/1476-9255-7-40.

Leukocyte oxygen radical production determines disease severity in the recurrent Guillain-Barré syndrome.

Journal of inflammation (London, England)

Natalia Mossberg, Oluf Andersen, Magnus Nordin, Staffan Nilsson, Ake Svedhem, Tomas Bergström, Kristoffer Hellstrand, Charlotta Movitz

Affiliations

  1. Department of Infectious Diseases, University of Gothenburg, Sweden. [email protected].

PMID: 20691112 PMCID: PMC2924308 DOI: 10.1186/1476-9255-7-40

Abstract

BACKGROUND: The recurrent Guillain-Barré syndrome (RGBS) is characterized by at least two GBS episodes with intervening remission. In a previous study of monophasic GBS, we reported that the magnitude of oxygen radical production ("respiratory burst") in peripheral blood leukocytes was inversely correlated to disease severity. The present study sought to establish a similar correlation in patients with RGBS.

METHODS: Oxygen radical production in leukocytes was induced by formyl-Met-Leu-Phe (fMLF), Trp-Lys-Tyr-Met-Val-Met-NH2 (WKYMVM), or phorbol myristate acetate (PMA) and assessed by quantifying superoxide anion formed by the leukocyte NADPH oxidase.

RESULTS: Disease severity, assessed using the MRC score, was negatively correlated to superoxide anion production triggered by fMLF or WKYMVM (p = 0.001 and 0.002, respectively; n = 10). Superoxide anion production also was significantly lower in RGBS patients with incomplete recovery after stimulation with fMLF (p = 0.004) or WKYMVM (p = 0.003).

CONCLUSION: We conclude that a lower respiratory burst in leukocytes is strongly associated with a severe course of RGBS.

References

  1. Muscle Nerve. 1991 Nov;14(11):1103-9 - PubMed
  2. Free Radic Biol Med. 1996;20(6):785-92 - PubMed
  3. Nat Immunol. 2004 Aug;5(8):818-27 - PubMed
  4. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12646-51 - PubMed
  5. Neurology. 2005 Jul 12;65(1):138-40 - PubMed
  6. Antioxid Redox Signal. 2007 Oct;9(10):1541-67 - PubMed
  7. J Neurol. 2004 Mar;251(3):261-8 - PubMed
  8. Pharmacol Rev. 2009 Jun;61(2):119-61 - PubMed
  9. J Neuroimmunol. 2009 Aug 18;213(1-2):131-4 - PubMed
  10. J Neuroimmunol. 2007 Dec;192(1-2):186-91 - PubMed
  11. J Neurol Neurosurg Psychiatry. 2009 Jan;80(1):56-9 - PubMed
  12. Eur Neurol. 2001;45(3):133-9 - PubMed
  13. J Immunol. 1996 Jan 1;156(1):42-7 - PubMed
  14. J Leukoc Biol. 2005 May;77(5):598-625 - PubMed
  15. Medicine (Baltimore). 2000 May;79(3):170-200 - PubMed
  16. Nat Genet. 2003 Jan;33(1):25-32 - PubMed
  17. Eur J Neurol. 2006 Apr;13(4):326-32 - PubMed
  18. Autoimmun Rev. 2003 Oct;2(6):364-9 - PubMed
  19. J Allergy Clin Immunol. 2008 Dec;122(6):1097-103 - PubMed
  20. J Immunol. 2009 Apr 1;182(7):4432-8 - PubMed
  21. Brain. 1992 Aug;115 ( Pt 4):1093-106 - PubMed
  22. J Infect Dis. 1983 Jul;148(1):82-92 - PubMed
  23. Scand J Clin Lab Invest Suppl. 1968;97:77-89 - PubMed
  24. Clin Immunol. 2008 Oct;129(1):90-102 - PubMed
  25. Electromyogr Clin Neurophysiol. 2004 Mar;44(2):95-102 - PubMed
  26. Dig Dis Sci. 2000 Jun;45(6):1121-9 - PubMed
  27. Br J Hosp Med. 1995 Apr 19-May 2;53(8):403-7 - PubMed
  28. J Immunol Methods. 1999 Dec 17;232(1-2):3-14 - PubMed
  29. J Neuroimmunol. 2006 Sep;178(1-2):156-60 - PubMed
  30. Am J Med. 2000 Jul;109(1):33-44 - PubMed
  31. Ann Neurol. 1990;27 Suppl:S21-4 - PubMed
  32. J Immunol. 2007 Aug 1;179(3):1431-7 - PubMed
  33. Trends Immunol. 2009 May;30(5):201-8 - PubMed
  34. J Immunol. 1985 Sep;135(3):2057-62 - PubMed

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