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Fornaro M, Martino M. Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management. Neuropsychiatr Dis Treat. 2010;6:209-18doi: 10.2147/ndt.s10361.
Fornaro, M., & Martino, M. (2010). Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management. Neuropsychiatric disease and treatment, 6209-18. https://doi.org/10.2147/ndt.s10361
Fornaro, Michele, and Martino, Matteo. "Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management." Neuropsychiatric disease and treatment vol. 6 (2010): 209-18. doi: https://doi.org/10.2147/ndt.s10361
Fornaro M, Martino M. Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management. Neuropsychiatr Dis Treat. 2010 Jun 24;6:209-18. doi: 10.2147/ndt.s10361. PMID: 20628627; PMCID: PMC2898164.
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Neuropsychiatr Dis Treat. 2010 Jun 24;6:209-18. doi: 10.2147/ndt.s10361.

Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management.

Neuropsychiatric disease and treatment

Michele Fornaro, Matteo Martino

Affiliations

  1. Department of Neuroscience, Section of Psychiatry, University of Genova, Genova, Italy.

PMID: 20628627 PMCID: PMC2898164 DOI: 10.2147/ndt.s10361

Abstract

BACKGROUND: Subjective tinnitus is a frequent, impairing condition, which may also cause neurotransmitter imbalance at the cochlea. Psychopharmacologic agents, although not being the first-line treatment for tinnitus, may modulate cochlear neurotransmission, thereby influencing the subjective tinnitus experience.

METHOD: A comprehensive review of MEDLINE literature (from January 1990-January 2010) was performed searching for: "tinnitus", major classes of psychopharmacological agents, and psychiatric disorders. The most relevant clinical evidence is reported briefly along with a concise description of the main neurotransmitters purported to be involved in tinnitus, in order to provide the reader with a rational evaluation of tinnitus therapy with psychopharmacological agents.

RESULTS: Although strong methodological issues limit the reliability of the current results, a broad number of psychopharmacological agents have already been considered for tinnitus, both as candidate triggers or potential therapies.

CONCLUSIONS: Selected psychopharmacological drugs may play a role in the clinical management of this disorder. While the rational use of these agents for the treatment of tinnitus should not be overlooked, research should be undertaken on their neuromodulating actions at the cochlea.

Keywords: cochlea; psychopharmacology; tinnitus

References

  1. Braz J Otorhinolaryngol. 2005 Sep-Oct;71(5):618-23 - PubMed
  2. B-ENT. 2007;3 Suppl 7:19-22 - PubMed
  3. B-ENT. 2007;3 Suppl 7:37-49 - PubMed
  4. Prog Brain Res. 2007;166:141-6 - PubMed
  5. Biol Psychiatry. 1995 Nov 15;38(10):694-5 - PubMed
  6. J Clin Psychopharmacol. 1996 Aug;16(4):324-8 - PubMed
  7. Kulak Burun Bogaz Ihtis Derg. 2006;16(1):29-36 - PubMed
  8. Otol Neurotol. 2007 Jan;28(1):11-5 - PubMed
  9. J Neurosci Res. 2004 Feb 15;75(4):585-96 - PubMed
  10. Prog Brain Res. 2007;166:335-8 - PubMed
  11. J Neurol Neurosurg Psychiatry. 2010 Apr;81(4):451-5 - PubMed
  12. J Thorac Oncol. 2009 Nov;4(11 Suppl 3):S1077-8 - PubMed
  13. J Acoust Soc Am. 1978 Nov;64(5):1386-91 - PubMed
  14. Med Sci Monit. 2009 Jun;15(6):PI35-9 - PubMed
  15. Br J Audiol. 1993 Feb;27(1):7-17 - PubMed
  16. Drugs. 2009 Jul 9;69(10):1319-38 - PubMed
  17. J Assoc Res Otolaryngol. 2007 Mar;8(1):105-18 - PubMed
  18. HNO. 2008 Jul;56(7):670-2 - PubMed
  19. Synapse. 2006 Aug;60(2):132-40 - PubMed
  20. Drugs Today (Barc). 2009 Aug;45(8):599-608 - PubMed
  21. Int Tinnitus J. 2004;10(1):17-23 - PubMed
  22. Am J Otolaryngol. 1999 Nov-Dec;20(6):351-62 - PubMed
  23. Am J Audiol. 2008 Dec;17(2):S170-5 - PubMed
  24. Auris Nasus Larynx. 1999 Oct;26(4):411-7 - PubMed
  25. Mol Pharmacol. 2008 Sep;74(3):595-604 - PubMed
  26. J Clin Psychopharmacol. 1981 Nov;1(6):404-6 - PubMed
  27. Nihon Jibiinkoka Gakkai Kaiho. 1992 Sep;95(9):1389-97 - PubMed
  28. J Headache Pain. 2010 Feb;11(1):83-4 - PubMed
  29. Int Tinnitus J. 2008;14(1):1-5 - PubMed
  30. Lancet. 1994 May 14;343(8907):1229-30 - PubMed
  31. Eur Arch Otorhinolaryngol. 2008 May;265(5):525-30 - PubMed
  32. J Clin Psychiatry. 2001;62 Suppl 20:42-8 - PubMed
  33. ORL J Otorhinolaryngol Relat Spec. 2006;68(1):14-19; discussion 20-2 - PubMed
  34. Arch Otolaryngol Head Neck Surg. 2007 Apr;133(4):390-7 - PubMed
  35. Otolaryngol Head Neck Surg. 1998 Mar;118(3 Pt 1):421 - PubMed
  36. Ann Otol Rhinol Laryngol. 1984 Jan-Feb;93(1 Pt 1):39-44 - PubMed
  37. Int Tinnitus J. 2002;8(1):50-3 - PubMed
  38. J Clin Psychopharmacol. 2006 Feb;26(1):32-9 - PubMed
  39. Arch Intern Med. 1993 Oct 11;153(19):2251-9 - PubMed
  40. Am J Otol. 1993 Jan;14(1):18-23 - PubMed
  41. Eur Arch Otorhinolaryngol. 2004 Nov;261(10):517-25 - PubMed
  42. Braz J Otorhinolaryngol. 2005 Jan-Feb;71(1):111-3 - PubMed
  43. Neuroscience. 2001;102(3):625-38 - PubMed
  44. Neurology. 1998 Jan;50(1):114-20 - PubMed
  45. Mol Pharmacol. 2001 Jul;60(1):183-9 - PubMed
  46. Neuroscience. 2005;132(4):1103-13 - PubMed
  47. J Neurosci. 2003 May 1;23(9):3944-52 - PubMed
  48. N Engl J Med. 1986 Oct 2;315(14):854-9 - PubMed
  49. J Otolaryngol. 2007 Aug;36(4):213-9 - PubMed
  50. Prog Brain Res. 2007;166:279-85 - PubMed
  51. Laryngoscope. 2006 May;116(5):675-81 - PubMed
  52. Neurosci Lett. 2003 May 29;343(1):21-4 - PubMed
  53. Ann Otol Rhinol Laryngol. 1988 Mar-Apr;97(2 Pt 1):120-3 - PubMed
  54. Otolaryngol Head Neck Surg. 2009 Jul;141(1):136-8 - PubMed
  55. J Neurol Neurosurg Psychiatry. 1998 Nov;65(5):803 - PubMed
  56. J Laryngol Otol. 1991 Jun;105(6):475-6 - PubMed
  57. Prog Brain Res. 2007;166:47-53 - PubMed
  58. Otolaryngol Clin North Am. 2003 Apr;36(2):383-8 - PubMed
  59. Am J Otol. 1999 Sep;20(5):627-31 - PubMed
  60. Hear Res. 2007 Apr;226(1-2):244-53 - PubMed
  61. Alzheimer Dis Assoc Disord. 2007 Jan-Mar;21(1):60-4 - PubMed
  62. J Psychopharmacol. 2008 Jul;22(5):574-5 - PubMed
  63. Prog Brain Res. 2007;166:263-71 - PubMed
  64. Biochem Pharmacol. 2009 Oct 1;78(7):712-9 - PubMed
  65. Prog Brain Res. 2007;166:323-30 - PubMed
  66. Am J Health Syst Pharm. 2009 Sep 15;66(18):1606, 1608 - PubMed
  67. ORL J Otorhinolaryngol Relat Spec. 1985;47(5):262-6 - PubMed
  68. Ear Nose Throat J. 2004 Feb;83(2):107-8, 110, 112 passim - PubMed
  69. Int J Neuropsychopharmacol. 2008 Dec;11(8):1169-80 - PubMed
  70. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD003853 - PubMed
  71. Ugeskr Laeger. 2008 Jan 28;170(5):354 - PubMed
  72. Scand Audiol. 1991;20(3):165-71 - PubMed
  73. J Clin Psychiatry. 1991 Aug;52(8):352 - PubMed
  74. Acta Otolaryngol. 1992;112(2):242-7 - PubMed
  75. Appl Psychophysiol Biofeedback. 2008 Sep;33(3):149-59 - PubMed
  76. South Med J. 2000 Oct;93(10):1030-1 - PubMed
  77. ORL J Otorhinolaryngol Relat Spec. 2006;68(1):43-6; discussion 46-7 - PubMed
  78. South Med J. 1983 Sep;76(9):1204-5 - PubMed
  79. Int Tinnitus J. 2006;12(2):140-4 - PubMed
  80. Intern Med. 2003 Nov;42(11):1153-4 - PubMed
  81. Alcohol Clin Exp Res. 2008 Jul;32(7):1105-10 - PubMed
  82. Acta Otorhinolaryngol Belg. 1983;37(5):697-705 - PubMed
  83. Niger J Med. 2008 Jan-Mar;17(1):95-7 - PubMed
  84. Neural Plast. 2007;2007:80904 - PubMed
  85. J Clin Psychopharmacol. 1988 Oct;8(5):359-62 - PubMed
  86. J Comp Neurol. 1992 Jun 22;320(4):501-8 - PubMed
  87. HNO. 2002 Nov;50(11):997-1004 - PubMed
  88. Am Fam Physician. 1995 Jun;51(8):1830 - PubMed
  89. Braz J Otorhinolaryngol. 2007 May-Jun;73(3):390-7 - PubMed
  90. Neuroreport. 1998 Jun 22;9(9):2109-14 - PubMed
  91. Mol Cell Neurosci. 2002 Jun;20(2):257-70 - PubMed
  92. Hear Res. 2005 Aug;206(1-2):200-26 - PubMed
  93. Drug Discov Today. 2005 Oct 1;10(19):1283-90 - PubMed
  94. Eur J Neurosci. 2005 Nov;22(10):2675-8 - PubMed
  95. Acta Otolaryngol. 2008 Jan;128(1):48-52 - PubMed
  96. Psychosom Med. 2005 Nov-Dec;67(6):981-8 - PubMed
  97. Neuroscience. 2007 Mar 16;145(2):715-26 - PubMed
  98. J Biol Regul Homeost Agents. 2009 Apr-Jun;23(2):103-10 - PubMed
  99. Ciba Found Symp. 1970;:241-73 - PubMed
  100. Ann Pharmacother. 1999 Mar;33(3):305-7 - PubMed
  101. Hear Res. 2000 Sep;147(1-2):261-74 - PubMed
  102. Hear Res. 1996 Aug;97(1-2):46-53 - PubMed
  103. J Clin Neurol. 2009 Mar;5(1):11-9 - PubMed
  104. J Psychiatr Res. 2010 Apr;44(5):263-70 - PubMed
  105. Int Tinnitus J. 1995;1(1):54-60 - PubMed
  106. J Otolaryngol. 2001 Oct;30(5):300-3 - PubMed
  107. Br J Audiol. 1994 Jun;28(3):125-9 - PubMed
  108. Med Sci Monit. 2009 Nov;15(11):PI55-60 - PubMed
  109. Auris Nasus Larynx. 2007 Mar;34(1):23-7 - PubMed

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