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Favier L, Ladoire L, Guiu B, et al. Carcinomatous Meningitis from Unknown Primary Carcinoma. Case Rep Oncol. 2009;2(3):177-183doi: 10.1159/000241985.
Favier, L., Ladoire, L., Guiu, B., Arnould, L., Guiu, S., Boichot, C., Isambert, N., Besancenot, J. F., Muller, M., & Ghiringhelli, F. (2009). Carcinomatous Meningitis from Unknown Primary Carcinoma. Case reports in oncology, 2(3), 177-183. https://doi.org/10.1159/000241985
Favier, L, et al. "Carcinomatous Meningitis from Unknown Primary Carcinoma." Case reports in oncology vol. 2,3 (2009): 177-183. doi: https://doi.org/10.1159/000241985
Favier L, Ladoire L, Guiu B, Arnould L, Guiu S, Boichot C, Isambert N, Besancenot JF, Muller M, Ghiringhelli F. Carcinomatous Meningitis from Unknown Primary Carcinoma. Case Rep Oncol. 2009 Oct 10;2(3):177-183. doi: 10.1159/000241985. PMID: 20737034; PMCID: PMC2914379.
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Case Rep Oncol. 2009 Oct 10;2(3):177-183. doi: 10.1159/000241985.

Carcinomatous Meningitis from Unknown Primary Carcinoma.

Case reports in oncology

L Favier, L Ladoire, B Guiu, L Arnould, S Guiu, C Boichot, N Isambert, J F Besancenot, M Muller, F Ghiringhelli

Affiliations

  1. Department of Medical Oncology, Center Georges Francois Leclerc, General Hospital, Dijon, France.

PMID: 20737034 PMCID: PMC2914379 DOI: 10.1159/000241985

Abstract

Carcinomatous meningitis (CM) occurs in 3 to 8% of cancer patients. Patients present with a focal symptom, and multifocal signs are often found following neurological examination. The gold standard for diagnosis remains the demonstration of carcinomatous cells in the cerebrospinal fluid on cytopathological examination. Despite the poor prognosis, palliative treatment could improve quality of life and, in some cases, overall survival. We report on a patient who presented with vertigo, tinnitus and left-sided hearing loss followed by progressive diffuse facial nerve paralysis. Lumbar cerebrospinal fluid confirmed the diagnosis of CM. However, no primary tumor was discovered, even after multiple invasive investigations. This is the first reported case in the English-language medical literature of CM resulting from a carcinoma of unknown primary origin.

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