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Mizrahi A, Czerniak A, Ohana P, et al. Treatment of ovarian cancer ascites by intra-peritoneal injection of diphtheria toxin A chain-H19 vector: a case report. J Med Case Rep. 2010;4:228doi: 10.1186/1752-1947-4-228.
Mizrahi, A., Czerniak, A., Ohana, P., Amiur, S., Gallula, J., Matouk, I., Abu-Lail, R., Birman, T., Hochberg, A., & Levy, T. (2010). Treatment of ovarian cancer ascites by intra-peritoneal injection of diphtheria toxin A chain-H19 vector: a case report. Journal of medical case reports, 4228. https://doi.org/10.1186/1752-1947-4-228
Mizrahi, Aya, et al. "Treatment of ovarian cancer ascites by intra-peritoneal injection of diphtheria toxin A chain-H19 vector: a case report." Journal of medical case reports vol. 4 (2010): 228. doi: https://doi.org/10.1186/1752-1947-4-228
Mizrahi A, Czerniak A, Ohana P, Amiur S, Gallula J, Matouk I, Abu-Lail R, Birman T, Hochberg A, Levy T. Treatment of ovarian cancer ascites by intra-peritoneal injection of diphtheria toxin A chain-H19 vector: a case report. J Med Case Rep. 2010 Jul 27;4:228. doi: 10.1186/1752-1947-4-228. PMID: 20663201; PMCID: PMC2918631.
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J Med Case Rep. 2010 Jul 27;4:228. doi: 10.1186/1752-1947-4-228.

Treatment of ovarian cancer ascites by intra-peritoneal injection of diphtheria toxin A chain-H19 vector: a case report.

Journal of medical case reports

Aya Mizrahi, Abraham Czerniak, Patricia Ohana, Smadar Amiur, Jennifer Gallula, Imad Matouk, Rasha Abu-Lail, Tatiana Birman, Abraham Hochberg, Tally Levy

Affiliations

  1. The Hebrew University of Jerusalem, Biological Chemistry, Jerusalem, 91905, Israel. [email protected].

PMID: 20663201 PMCID: PMC2918631 DOI: 10.1186/1752-1947-4-228

Abstract

INTRODUCTION: Ovarian cancer ascitic fluid, which contains malignant cells, is usually present in women with an advanced stage disease. There are currently no effective therapies for the treatment of ovarian cancer ascitic fluid. We developed a new therapeutic strategy to target expression of the diphtheria toxin fragment A gene in ovarian tumor cells under the control of H19 regulatory sequences.

CASE PRESENTATION: A 64-year-old Caucasian woman was diagnosed with a stage IIIc epithelial ovarian cancer. She suffered from progressive disease, accumulation of malignant ascites that needed to be drained weekly, abdominal pain, vomiting, anorexia and severe weakness. Infusion of the diphtheria toxin A chain-H19 plasmid into the peritoneum of our patient resulted in complete resolution of the ascites with minimum adverse events.

CONCLUSION: On the basis of this preliminary experience, we are currently conducting an extensive Phase I study on a larger number of patients in order to assess the safety and preliminary efficacy of this novel patient-oriented treatment approach.

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