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Calder IC, Funder CC, Green CR, et al. Nephrotoxic lesions from 5-aminosalicylic Acid. Br Med J. 1972;1(5793):152-4doi: 10.1136/bmj.1.5793.152.
Calder, I. C., Funder, C. C., Green, C. R., Ham, K. N., & Tange, J. D. (1972). Nephrotoxic lesions from 5-aminosalicylic Acid. British medical journal, 1(5793), 152-4. https://doi.org/10.1136/bmj.1.5793.152
Calder, I C, et al. "Nephrotoxic lesions from 5-aminosalicylic Acid." British medical journal vol. 1,5793 (1972): 152-4. doi: https://doi.org/10.1136/bmj.1.5793.152
Calder IC, Funder CC, Green CR, Ham KN, Tange JD. Nephrotoxic lesions from 5-aminosalicylic Acid. Br Med J. 1972 Jan 15;1(5793):152-4. doi: 10.1136/bmj.1.5793.152. PMID: 20791817; PMCID: PMC1787127.
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Br Med J. 1972 Jan 15;1(5793):152-4. doi: 10.1136/bmj.1.5793.152.

Nephrotoxic lesions from 5-aminosalicylic Acid.

British medical journal

I C Calder, C C Funder, C R Green, K N Ham, J D Tange

PMID: 20791817 PMCID: PMC1787127 DOI: 10.1136/bmj.1.5793.152

Abstract

5-Aminosalicylic acid given to rats as a single intravenous injection led to necrosis of the proximal convoluted tubules and of the renal papilla. These two lesions developed at the same time and the cortical lesions did not appear to be a consequence of the renal papillary necrosis. Since the compound possesses the molecular structure both of a phenacetin derivative and of a salicylate these observations may be relevant to the problem of renal damage incident to abuse of analgesic compounds and suggest the possibility that in this syndrome cortical lesions may develop independently of renal papillary necrosis.

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