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Ameer NH, Lee JH, Choi MA, et al. The Effects of Glutamate NMDA Receptor Antagonist MK-801 on Gastrointestinal Motility after Middle Cerebral Artery Occlusion in Rats. Korean J Physiol Pharmacol. 2010;14(3):151-6doi: 10.4196/kjpp.2010.14.3.151.
Ameer, N. H., Lee, J. H., Choi, M. A., Jin, G. S., Kim, M. S., & Park, B. R. (2010). The Effects of Glutamate NMDA Receptor Antagonist MK-801 on Gastrointestinal Motility after Middle Cerebral Artery Occlusion in Rats. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 14(3), 151-6. https://doi.org/10.4196/kjpp.2010.14.3.151
Ameer, Nasir Hussin, et al. "The Effects of Glutamate NMDA Receptor Antagonist MK-801 on Gastrointestinal Motility after Middle Cerebral Artery Occlusion in Rats." The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol. 14,3 (2010): 151-6. doi: https://doi.org/10.4196/kjpp.2010.14.3.151
Ameer NH, Lee JH, Choi MA, Jin GS, Kim MS, Park BR. The Effects of Glutamate NMDA Receptor Antagonist MK-801 on Gastrointestinal Motility after Middle Cerebral Artery Occlusion in Rats. Korean J Physiol Pharmacol. 2010 Jun;14(3):151-6. doi: 10.4196/kjpp.2010.14.3.151. Epub 2010 Jun 30. PMID: 20631887; PMCID: PMC2902806.
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Korean J Physiol Pharmacol. 2010 Jun;14(3):151-6. doi: 10.4196/kjpp.2010.14.3.151. Epub 2010 Jun 30.

The Effects of Glutamate NMDA Receptor Antagonist MK-801 on Gastrointestinal Motility after Middle Cerebral Artery Occlusion in Rats.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Nasir Hussin Ameer, Jae Hee Lee, Myoung Ae Choi, Guang-Shi Jin, Min Sun Kim, Byung Rim Park

Affiliations

  1. Department of Physiology, Wonkwang University School of Medicine, and Brain Research Institute at Wonkwang University, Iksan 570-749, Korea.

PMID: 20631887 PMCID: PMC2902806 DOI: 10.4196/kjpp.2010.14.3.151

Abstract

This study was performed to investigate the role of glutamate neurotransmitter system on gastrointestinal motility in a middle cerebral artery occlusion (MCAO) model of rats. The right middle cerebral artery was occluded by surgical operation, and intestinal transit and geometric center as a parameter of gastrointestinal motility and expression of c-Fos protein in the insular cortex and cingulate cortex were measured at 2 and 12 h after MCAO. Intestinal transit was 66.3+/-7.5% and 62.3+/-5.7% 2 and 12 h after sham operation, respectively, and MCAO significantly decreased intestinal transit to 39.0+/-3.5% and 47.0+/-5.1% at 2 and 12 h after the occlusion, respectively (p<0.01). The geometric center was 5.6+/-0.4 and 5.2+/-0.9 at 2 and 12 h after sham operation, respectively, and MCAO significantly decreased geometric center to 2.9+/-0.8 and 3.0+/-0.3 at 2 and 12 h after the occlusion, respectively (p<0.01). In control animals, injection of atropine decreased intestinal transit to 35.9+/-5.2%, and injection of glutamate NMDA receptor antagonist, MK-801, decreased intestinal transit to 28.8+/-9.5%. Pretreatment with MK-801, a glutamate NMDA receptor antagonist, in the MCAO group decreased intestinal transit to 11.8+/-3.2%, which was significantly decreased compared to MCAO group (p<0.01). MCAO markedly increased the expression of c-Fos protein in the insular cortex and cingulate cortex ipsilateral to the occlusion 2 h after MCAO, and pretreatment with MK-801 produced marked reduction of c-Fos protein expression compared to MCAO group (p<0.01). These results suggest that modulation of gastrointestinal motility after MCAO might be partially mediated through a glutamate NMDA receptor system.

Keywords: Glutamate; Insular cortex; Intestinal transit; MCAO; MK-801

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