Display options
Cite
Doggrell SA, Christensen AM. Does the p38 MAP kinase inhibitor pamapimod have potential for the treatment of rheumatoid arthritis?. Expert Opin Pharmacother. 2010;11(14):2437-42doi: 10.1517/14656566.2010.507631.
Doggrell, S. A., & Christensen, A. M. (2010). Does the p38 MAP kinase inhibitor pamapimod have potential for the treatment of rheumatoid arthritis?. Expert opinion on pharmacotherapy, 11(14), 2437-42. https://doi.org/10.1517/14656566.2010.507631
Doggrell, Sheila A, and Christensen, Anne-Marie. "Does the p38 MAP kinase inhibitor pamapimod have potential for the treatment of rheumatoid arthritis?." Expert opinion on pharmacotherapy vol. 11,14 (2010): 2437-42. doi: https://doi.org/10.1517/14656566.2010.507631
Doggrell SA, Christensen AM. Does the p38 MAP kinase inhibitor pamapimod have potential for the treatment of rheumatoid arthritis?. Expert Opin Pharmacother. 2010 Oct;11(14):2437-42. doi: 10.1517/14656566.2010.507631. PMID: 20666701.
Copy Download .nbib Format: NLM
Share it on

Expert Opin Pharmacother. 2010 Oct;11(14):2437-42. doi: 10.1517/14656566.2010.507631.

Does the p38 MAP kinase inhibitor pamapimod have potential for the treatment of rheumatoid arthritis?.

Expert opinion on pharmacotherapy

Sheila A Doggrell, Anne-Marie Christensen

Affiliations

  1. Queensland University of Technology, Discipline of Medical Sciences, Faculty of Science and Technology, GPO 2343, QLD 4001, Brisbane, Australia. [email protected]

PMID: 20666701 DOI: 10.1517/14656566.2010.507631

Abstract

Methotrexate alone or in combination with other agents is the standard treatment for moderate-to-severe rheumatoid arthritis. As biological agents are expensive, they are not usually used until methotrexate has failed to give a good response. Thus, there is scope for the development of cheaper drugs that can be used instead of methotrexate or in addition to methotrexate. Pamapimod is a p38α inhibitor being developed for use in the treatment of rheumatoid arthritis. The objective of this review was to evaluate the recent clinical trials of pamapimod in subjects with rheumatoid arthritis. There is no clear-cut evidence that pamapimod alone or in the presence of methotrexate is efficacious in subjects with rheumatoid arthritis but it does cause adverse effects. It is unlikely that pamapimod will be useful in the treatment of rheumatoid arthritis.

Publication Types