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Bouillet L. Hereditary angioedema in women. Allergy Asthma Clin Immunol. 2010;6(1):17doi: 10.1186/1710-1492-6-17.
Bouillet, L. (2010). Hereditary angioedema in women. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 6(1), 17. https://doi.org/10.1186/1710-1492-6-17
Bouillet, Laurence. "Hereditary angioedema in women." Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology vol. 6,1 (2010): 17. doi: https://doi.org/10.1186/1710-1492-6-17
Bouillet L. Hereditary angioedema in women. Allergy Asthma Clin Immunol. 2010 Jul 28;6(1):17. doi: 10.1186/1710-1492-6-17. PMID: 20667120; PMCID: PMC2918592.
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Allergy Asthma Clin Immunol. 2010 Jul 28;6(1):17. doi: 10.1186/1710-1492-6-17.

Hereditary angioedema in women.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

Laurence Bouillet

Affiliations

  1. National French Reference Centre of Angioedema, Internal Medicine Department, Grenoble University Hospital, France. [email protected].

PMID: 20667120 PMCID: PMC2918592 DOI: 10.1186/1710-1492-6-17

Abstract

Women with hereditary angioedema (HAE) are more likely to be symptomatic that men. Hormonal factors (puberty, contraception, pregnancy,....) play a significant role in the precipitation or worsening of the condition in women. So, combined contraceptive pills are not indicated and progestogen pill must be preferred. During pregnancy, attack rate can increase (38-48% of women). C1Inhibitor concentrate and tranexamic acid can be used during pregnancy. Attenuated androgens for long term prophylaxis are effective but side effects appear more often in female patients. These side effects are dose dependant and can be attenuated by titrating the dose down the lowest effective level.

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