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Yoo SJ, Grosse-Wortmann L, Hamilton RM. Magnetic resonance imaging assessment of arrhythmogenic right ventricular cardiomyopathy/dysplasia in children. Korean Circ J. 2010;40(8):357-67doi: 10.4070/kcj.2010.40.8.357.
Yoo, S. J., Grosse-Wortmann, L., & Hamilton, R. M. (2010). Magnetic resonance imaging assessment of arrhythmogenic right ventricular cardiomyopathy/dysplasia in children. Korean circulation journal, 40(8), 357-67. https://doi.org/10.4070/kcj.2010.40.8.357
Yoo, Shi-Joon, et al. "Magnetic resonance imaging assessment of arrhythmogenic right ventricular cardiomyopathy/dysplasia in children." Korean circulation journal vol. 40,8 (2010): 357-67. doi: https://doi.org/10.4070/kcj.2010.40.8.357
Yoo SJ, Grosse-Wortmann L, Hamilton RM. Magnetic resonance imaging assessment of arrhythmogenic right ventricular cardiomyopathy/dysplasia in children. Korean Circ J. 2010 Aug;40(8):357-67. doi: 10.4070/kcj.2010.40.8.357. Epub 2010 Aug 31. PMID: 20830248; PMCID: PMC2933459.
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Korean Circ J. 2010 Aug;40(8):357-67. doi: 10.4070/kcj.2010.40.8.357. Epub 2010 Aug 31.

Magnetic resonance imaging assessment of arrhythmogenic right ventricular cardiomyopathy/dysplasia in children.

Korean circulation journal

Shi-Joon Yoo, Lars Grosse-Wortmann, Robert M Hamilton

Affiliations

  1. Department of Diagnostic Imaging, The Hospital for Sick Children and Research Institute, University of Toronto, Ontario, Canada.

PMID: 20830248 PMCID: PMC2933459 DOI: 10.4070/kcj.2010.40.8.357

Abstract

Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a genetically determined disease that progresses continuously from conception and throughout life. ARVC/D manifests predominantly in young adulthood. Early identification of the concealed cases in childhood is of utmost importance for the prevention of sudden cardiac death later in life. Magnetic resonance imaging (MRI) is routinely requested in patients with a confirmed or suspected diagnosis of ARVC/D and in family members of the patients with ARVC/D. Although the utility of MRI in the assessment of ARVC/D is well recognized in adults, MRI is a low-yield test in children as the anatomical, histological, and functional changes are frequently subtle or not present in the early phase of the disease. MRI findings of ARVC/D include morphologic changes such as right ventricular dilatation, wall thinning, and aneurismal outpouchings, as well as abnormal tissue characteristics such as myocardial fibrosis and fatty infiltration, and functional abnormalities such as global ventricular dysfunction and regional wall motion abnormalities. Among these findings, regional wall motion abnormalities are the most reliable MRI findings both in children and adults, while myocardial fibrosis and fat infiltration are rarely seen in children. Therefore, an MRI protocol should be tailored according to the patient's age and compliance, as well as the presence of other findings, instead of using the protocol that is used for adults. We propose that MRI in children with ARVC/D should focus on the detection of regional wall motion abnormalities and global ventricular function by using a cine imaging sequence and that the sequences for myocardial fat and late gadolinium enhancement of the myocardium are reserved for those who show abnormal findings at cine imaging. Importantly, MRI should be performed and interpreted by experienced examiners to reduce the number of false positive and false negative readings.

Keywords: Arrhythmogenic right ventricular cardiomyopathy/dysplasia; Children; Magnetic resonance imaging

References

  1. Heart Rhythm. 2009 Apr;6(4):571-5 - PubMed
  2. Radiographics. 2002 May-Jun;22(3):639-48; discussion 649-50 - PubMed
  3. Circulation. 2010 Apr 6;121(13):1533-41 - PubMed
  4. Circulation. 2004 Oct 5;110(14):1879-84 - PubMed
  5. AJR Am J Roentgenol. 1993 Sep;161(3):549-55 - PubMed
  6. Heart. 2009 May;95(9):766-73 - PubMed
  7. AJR Am J Roentgenol. 2007 May;188(5):W423-7 - PubMed
  8. AJR Am J Roentgenol. 1994 Apr;162(4):809-12 - PubMed
  9. Lancet. 2009 Apr 11;373(9671):1289-300 - PubMed
  10. Circulation. 2003 Dec 16;108(24):3000-5 - PubMed
  11. Am J Cardiol. 1992 Dec 15;70(20):1589-95 - PubMed
  12. Annu Rev Med. 2010;61:233-53 - PubMed
  13. J Cardiovasc Magn Reson. 2005;7(4):649-55 - PubMed
  14. Circ Cardiovasc Imaging. 2010 May;3(3):290-7 - PubMed
  15. Curr Opin Cardiol. 2008 Jan;23(1):38-45 - PubMed
  16. Circulation. 2007 Apr 3;115(13):1710-20 - PubMed
  17. Cardiovasc Pathol. 2010 Jul-Aug;19(4):207-17 - PubMed
  18. Acta Cardiol. 1999 Aug;54(4):189-94 - PubMed
  19. Circ Cardiovasc Genet. 2009 Oct;2(5):428-35 - PubMed
  20. Radiology. 2004 Jul;232(1):38-48 - PubMed
  21. Cardiology. 2003;99(3):153-62 - PubMed
  22. JAMA. 2006 Oct 4;296(13):1593-601 - PubMed
  23. Circ Cardiovasc Genet. 2009 Oct;2(5):418-27 - PubMed
  24. J Am Coll Cardiol. 2005 Jan 4;45(1):98-103 - PubMed
  25. Circulation. 1998 Apr 28;97(16):1571-80 - PubMed
  26. Heart Rhythm. 2009 Jul;6(7):984-92 - PubMed
  27. Circ Heart Fail. 2009 May;2(3):253-61 - PubMed
  28. Ann Noninvasive Electrocardiol. 2003 Apr;8(2):161-9 - PubMed
  29. J Am Coll Cardiol. 2009 Apr 14;53(15):1300-1 - PubMed
  30. Circ Cardiovasc Genet. 2009 Oct;2(5):415-7 - PubMed
  31. Am J Cardiol. 2006 Apr 15;97(8):1232-7 - PubMed
  32. Eur Heart J. 1995 Nov;16(11):1619-24 - PubMed
  33. Am Heart J. 2008 Jan;155(1):147-53 - PubMed
  34. J Am Coll Cardiol. 2007 Nov 6;50(19):1813-21 - PubMed
  35. J Am Coll Cardiol. 2009 Apr 14;53(15):1289-99 - PubMed
  36. N Engl J Med. 2009 Mar 12;360(11):1075-84 - PubMed
  37. Br Heart J. 1994 Mar;71(3):215-8 - PubMed
  38. J Cardiovasc Magn Reson. 2008 May 08;10:20 - PubMed
  39. AJR Am J Roentgenol. 2003 Apr;180(4):1135-41 - PubMed
  40. Eur Heart J. 2010 Jan;31(2):243-59 - PubMed
  41. J Am Coll Cardiol. 2006 Nov 21;48(10):2132-40 - PubMed
  42. J Magn Reson Imaging. 2008 Dec;28(6):1379-85 - PubMed
  43. J Am Coll Cardiol. 2006 Dec 5;48(11):2277-84 - PubMed
  44. J Cardiovasc Electrophysiol. 2003 May;14(5):476-82 - PubMed

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