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Zygulska A. Radiotherapy in the treatment of Graves ophthalmopathy-to do it or not?. J Ocul Biol Dis Infor. 2009;3(1):1-11doi: 10.1007/s12177-009-9021-y.
Zygulska, A. (2009). Radiotherapy in the treatment of Graves ophthalmopathy-to do it or not?. Journal of ocular biology, diseases, and informatics, 3(1), 1-11. https://doi.org/10.1007/s12177-009-9021-y
Zygulska, Aneta. "Radiotherapy in the treatment of Graves ophthalmopathy-to do it or not?." Journal of ocular biology, diseases, and informatics vol. 3,1 (2009): 1-11. doi: https://doi.org/10.1007/s12177-009-9021-y
Zygulska A. Radiotherapy in the treatment of Graves ophthalmopathy-to do it or not?. J Ocul Biol Dis Infor. 2009 Oct 06;3(1):1-11. doi: 10.1007/s12177-009-9021-y. PMID: 20835395; PMCID: PMC2933001.
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J Ocul Biol Dis Infor. 2009 Oct 06;3(1):1-11. doi: 10.1007/s12177-009-9021-y.

Radiotherapy in the treatment of Graves ophthalmopathy-to do it or not?.

Journal of ocular biology, diseases, and informatics

Aneta Zygulska

Affiliations

  1. Szpital Uniwersytecki, Krakow, Poland.

PMID: 20835395 PMCID: PMC2933001 DOI: 10.1007/s12177-009-9021-y

Abstract

To the objective of this study is to evaluate the role and toxicity of radiotherapy in the treatment of Graves ophthalmopathy. In the years 2000-2003, 121 patients with malignant exophthalmos were treated with radiotherapy of the retrobulbar area to the total dose of 20 Gy in ten fractions with a 6 MeV photon beam. The treatment was performed by the team of the Clinic of Oncology of the Jagiellonian University Medical College in Cracow. The radiotherapy was preceded by intravenous steroid therapy: methylprednisolone acetate administered at the dose of 2 g/week for four consecutive weeks. The highest efficacy, expressed as improvement of all ocular symptoms, was observed for the combined treatment. Female and non-diabetic patients responded positively to the combined treatment. Radiotherapy combined with steroid therapy in the treatment of Graves ophthalmopathy seems to be an effective treatment for strictly defined indications. In the treatment of Graves-Basedow disease, radiotherapy is a well-tolerated treatment modality. Diabetes is a factor that worsens prognosis in Graves ophthalmopathy and female sex is a favourable factor for this condition.

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