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Dimopoulos G, Tsangaris I, Poulakou G, et al. Post-operative Aspergillus mediastinitis in a man who was immunocompetent: a case report. J Med Case Rep. 2010;4:312doi: 10.1186/1752-1947-4-312.
Dimopoulos, G., Tsangaris, I., Poulakou, G., Panayiotides, J., Tsaknis, G., Orfanos, S., & Armaganides, A. (2010). Post-operative Aspergillus mediastinitis in a man who was immunocompetent: a case report. Journal of medical case reports, 4312. https://doi.org/10.1186/1752-1947-4-312
Dimopoulos, George, et al. "Post-operative Aspergillus mediastinitis in a man who was immunocompetent: a case report." Journal of medical case reports vol. 4 (2010): 312. doi: https://doi.org/10.1186/1752-1947-4-312
Dimopoulos G, Tsangaris I, Poulakou G, Panayiotides J, Tsaknis G, Orfanos S, Armaganides A. Post-operative Aspergillus mediastinitis in a man who was immunocompetent: a case report. J Med Case Rep. 2010 Sep 23;4:312. doi: 10.1186/1752-1947-4-312. PMID: 20863378; PMCID: PMC2955057.
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J Med Case Rep. 2010 Sep 23;4:312. doi: 10.1186/1752-1947-4-312.

Post-operative Aspergillus mediastinitis in a man who was immunocompetent: a case report.

Journal of medical case reports

George Dimopoulos, Iraklis Tsangaris, Garyphalia Poulakou, John Panayiotides, George Tsaknis, Stylianos Orfanos, Apostolos Armaganides

Affiliations

  1. Second Department of Critical Care Medicine, 'ATTIKON' University Hospital, University of Athens Medical School, Athens Greece. [email protected].

PMID: 20863378 PMCID: PMC2955057 DOI: 10.1186/1752-1947-4-312

Abstract

INTRODUCTION: Aspergillus spp. infections mainly affect patients who are immunocompromised, and are extremely rare in immunocompetent individuals.

CASE PRESENTATION: Aspergillus post-operative mediastinitis is considered to be a devastating infection, usually affecting patients undergoing cardiothoracic surgery with specific predisposing factors. We describe the case of an immunocompetent 68-year-old Caucasian man with severe chronic thromboembolic pulmonary hypertension, who underwent pulmonary thromboendarterectomy and developed post-operative mediastinitis due to Aspergillus flavus. The environmental control did not reveal the source of A. flavus infection and, despite combined antifungal therapy, our patient died as a result of septic shock and multiple organ failure.

CONCLUSION: Aspergillus mediastinitis mainly affects patients after cardiosurgery operations with predisposing factors, and it is unusual in patients who are immunocompetent. The identification of the Aspergillus spp. source is often difficult, and there are no guidelines for the administration of pre-emptive therapy in this population of at-risk patients.

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