Korean J Urol. 2010 Aug;51(8):550-6. doi: 10.4111/kju.2010.51.8.550. Epub 2010 Aug 18.
Effect of Sertraline on Current-Source Distribution of the High Beta Frequency Band: Analysis of Electroencephalography under Audiovisual Erotic Stimuli in Healthy, Right-Handed Males.
Korean journal of urology
Seung Hyun Lee, Jae Seog Hyun, Oh-Young Kwon
Affiliations
Affiliations
- Department of Urology, School of Medicine, Gyeongsang National University, Jinju, Korea.
PMID: 20733961
PMCID: PMC2924559 DOI: 10.4111/kju.2010.51.8.550
Abstract
PURPOSE: The purpose of this study was to examine the cerebral changes in high beta frequency oscillations (22-30 Hz) induced by sertraline and by audiovisual erotic stimuli in healthy adult males.
MATERIALS AND METHODS: Scalp electroencephalographies (EEGs) were conducted twice in 11 healthy, right-handed males, once before sertraline intake and again 4 hours thereafter. The EEGs included four sessions recorded sequentially while the subjects were resting, watching a music video, resting, and watching an erotic video for 3 minutes, 5 minutes, 3 minutes, and 5 minutes, respectively. We performed frequency-domain analysis using the EEGs with a distributed model of current-source analysis. The statistical nonparametric maps were obtained from the sessions of watching erotic and music videos (p<0.05).
RESULTS: The erotic stimuli decreased the current-source density of the high beta frequency band in the middle frontal gyrus, the precentral gyrus, the postcentral gyrus, and the supramarginal gyrus of the left cerebral hemisphere in the baseline EEGs taken before sertraline intake (p<0.05). The erotic stimuli did not induce any changes in current-source distribution of the brain 4 hours after sertraline intake.
CONCLUSIONS: It is speculated that erotic stimuli may decrease the function of the middle frontal gyrus, the precentral gyrus, the postcentral gyrus, and the supramarginal gyrus of the left cerebral hemisphere in healthy adult males. This change may debase the inhibitory control of the brain against erotic stimuli. Sertraline may reduce the decrement in inhibitory control.
Keywords: Electroencephalography; Serotonin uptake inhibitors; Sexual behavior
References
- Brain. 1996 Apr;119 ( Pt 2):377-92 - PubMed
- Pharmacol Biochem Behav. 1994 Sep;49(1):121-7 - PubMed
- Psychiatry Res. 1999 Jun 30;90(3):169-79 - PubMed
- Science. 2009 May 1;324(5927):646-8 - PubMed
- Electroencephalogr Clin Neurophysiol. 1993 Jan;86(1):1-6 - PubMed
- Psychiatry Investig. 2009 Jun;6(2):85-95 - PubMed
- Int J Impot Res. 2006 Sep-Oct;18(5):452-7 - PubMed
- Neurosci Lett. 2009 Dec 25;467(2):76-80 - PubMed
- Clin Neurophysiol. 2001 Dec;112(12):2288-92 - PubMed
- Brain Cogn. 1987 Apr;6(2):175-83 - PubMed
- Clin Neurophysiol. 2005 Dec;116(12):2810-8 - PubMed
- Clin Neurophysiol. 2006 Dec;117(12):2615-26 - PubMed
- Brain Topogr. 1995 Summer;7(4):321-30 - PubMed
- Brain Res. 1990 May 7;515(1-2):303-8 - PubMed
- Int J Psychophysiol. 1994 Oct;18(1):49-65 - PubMed
- Epilepsia. 2010 Feb;51 Suppl 1:63-5 - PubMed
- Am J Clin Nutr. 2007 Sep;86(3):573-9 - PubMed
- J Neurol. 2002 Oct;249(10):1404-8 - PubMed
- J Sex Med. 2006 Sep;3 Suppl 4:303-8 - PubMed
- Neuroimage. 1999 Jan;9(1):135-44 - PubMed
- J Urol. 1998 Jun;159(6):1935-8 - PubMed
- Clin Neurophysiol. 1999 Jan;110(1):106-14 - PubMed
- Psychophysiology. 1996 Jul;33(4):317-33 - PubMed
- Clin Neurophysiol. 2004 Oct;115(10):2195-222 - PubMed
- J Sex Med. 2008 Jun;5(6):1474-81 - PubMed
- J Neurosci. 2006 Jan 4;26(1):186-92 - PubMed
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