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Koo YJ, Lee JE, Hong SR, et al. Co-occurrence of an adenoma malignum and an endocervical-type adenocarcinoma of the uterine cervix in a woman with Peutz-Jeghers syndrome. J Gynecol Oncol. 2010;21(3):203-6doi: 10.3802/jgo.2010.21.3.203.
Koo, Y. J., Lee, J. E., Hong, S. R., & Kwon, Y. S. (2010). Co-occurrence of an adenoma malignum and an endocervical-type adenocarcinoma of the uterine cervix in a woman with Peutz-Jeghers syndrome. Journal of gynecologic oncology, 21(3), 203-6. https://doi.org/10.3802/jgo.2010.21.3.203
Koo, Yu-Jin, et al. "Co-occurrence of an adenoma malignum and an endocervical-type adenocarcinoma of the uterine cervix in a woman with Peutz-Jeghers syndrome." Journal of gynecologic oncology vol. 21,3 (2010): 203-6. doi: https://doi.org/10.3802/jgo.2010.21.3.203
Koo YJ, Lee JE, Hong SR, Kwon YS. Co-occurrence of an adenoma malignum and an endocervical-type adenocarcinoma of the uterine cervix in a woman with Peutz-Jeghers syndrome. J Gynecol Oncol. 2010 Sep;21(3):203-6. doi: 10.3802/jgo.2010.21.3.203. Epub 2010 Sep 28. PMID: 20922146; PMCID: PMC2948231.
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J Gynecol Oncol. 2010 Sep;21(3):203-6. doi: 10.3802/jgo.2010.21.3.203. Epub 2010 Sep 28.

Co-occurrence of an adenoma malignum and an endocervical-type adenocarcinoma of the uterine cervix in a woman with Peutz-Jeghers syndrome.

Journal of gynecologic oncology

Yu-Jin Koo, Ji-Eun Lee, Sung-Ran Hong, Yong-Soon Kwon

Affiliations

  1. Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea.

PMID: 20922146 PMCID: PMC2948231 DOI: 10.3802/jgo.2010.21.3.203

Abstract

We report a rare co-occurrence of an adenoma malignum and an adenocarcinoma in a 30-year-old woman with Peutz-Jeghers syndrome. The woman was diagnosed with Peutz-Jeghers syndrome based on an endoscopic biopsy after vaginal bleeding. A pelvic examination and an MRI revealed the co-occurrence of a 4×5 cm protruding adenocarcinoma of FIGO stage Ib2 based on a punch biopsy and a 4.5×5.7 cm multilocular cystic mass above the solid cancer. The patient received two courses of neoadjuvant chemotherapy, followed by a laparoscopic radical hysterectomy with pelvic lymph node dissection. Pathologic findings were consistent with adenocarcinoma (40%) and adenoma malignum (60%) confined to the cervix. Three courses of adjuvant chemotherapy were performed and no clinical evidence of recurrence was seen during a 12 month follow-up period. This study will contribute to defining the best diagnosis and treatment for these rare complicating tumors.

Keywords: Adenocarcinoma; Adenoma malignum; Peutz-Jeghers syndrome

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