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J Brachial Plex Peripher Nerve Inj. 2010 Aug 31;5:15. doi: 10.1186/1749-7221-5-15.

Possible role of alpha-lipoic acid in the treatment of peripheral nerve injuries.

Journal of brachial plexus and peripheral nerve injury

Maurizio Ranieri, Manuela Sciuscio, Annamaria Cortese, Marilena Stasi, Francesco Panza, Marisa Megna, Pietro Fiore, Andrea Santamato

Affiliations

  1. Department of Physical Medicine and Rehabilitation, University of Foggia, Foggia, Italy. [email protected].

PMID: 20807428 PMCID: PMC2939615 DOI: 10.1186/1749-7221-5-15

Abstract

Recent findings on the antioxidant effects of pretreatment with α-lipoic acid (α-LA) on the crush injury of rat sciatic nerve confirm the possible usefulness of α-LA administration in humans with peripheral nerve injuries. We discussed this issue in relation with our recent results in which the combined employment of α-LA and γ-linolenic acid with a rehabilitation program for six weeks reduced sensory symptoms and neuropathic pain in patients with compressive radiculopathy syndrome from disc-nerve root conflict in comparison with patients submitted to rehabilitation program alone for six weeks.

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