Clin Epidemiol. 2010 Aug 09;2:85-9. doi: 10.2147/clep.s10216.
Incidence and risk of chondrolysis in Denmark: A nationwide population-based study.
Clinical epidemiology
Christian F Christiansen, Sandra K Thygesen, Lars Pedersen
Affiliations
Affiliations
- Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
PMID: 20865107
PMCID: PMC2943176 DOI: 10.2147/clep.s10216
Abstract
BACKGROUND: Chondrolysis is a rare disease with destruction of cartilage of joints. Incidence and risk factors have not been studied in a formal epidemiologic population-based setting.
METHODS: We used the Danish National Registry of Patients (NRP) covering all Danish hospitals to identify all cases of chondrolysis from 1994 to 2008. Incidence rates were estimated using the general population as the denominator. For each chondrolysis patient, 10 age-matched population controls were sampled for a case-control analysis. For cases and controls, we ascertained in the NRP history of diabetes, rheumatoid arthritis, orthopedic surgery, including surgery of shoulder and upper arm, injury to shoulder girdle or upper arm, and treatment with pain pump. We determined the prevalence of these risk factors in cases and controls, and computed odds ratios (OR).
RESULTS: We identified 43 patients with chondrolysis in the 15-year study period. The incidence rate was 5.5 per 10,000,000 person-years. Diabetes was more prevalent in chondrolysis cases, compared with the 430 controls (OR = 6.7; 95% confidence intervals [CI]: 1.1-39.9). Orthopedic surgery was also associated with an increased risk of chondrolysis (OR = 28.8, 95% CI: 11.0-75.6), while previous injury was not (OR = 0.8; 95% CI: 0.1-5.9).
CONCLUSION: Chondrolysis was rarely diagnosed in Denmark. Diabetes and orthopedic surgery may be risk factors.
Keywords: epidemiology; incidence; risk factors; surgery
References
- J Shoulder Elbow Surg. 2009 Sep-Oct;18(5):742-7 - PubMed
- Acta Orthop Scand. 1997 Aug;68(4):401-2 - PubMed
- BMC Med Res Methodol. 2011 May 28;11:83 - PubMed
- Am J Sports Med. 2004 Mar;32(2):509-15 - PubMed
- Eur J Gynaecol Oncol. 2005;26(3):266-70 - PubMed
- J Med Syst. 1996 Feb;20(1):1-10 - PubMed
- J Bone Joint Surg Am. 2005 Mar;87(3):616-21 - PubMed
- Am J Sports Med. 2007 Oct;35(10):1628-34 - PubMed
- J Pediatr Orthop. 2005 Sep-Oct;25(5):702-4 - PubMed
- Science. 2000 Mar 31;287(5462):2398-9 - PubMed
- Arthroscopy. 2007 Jul;23(7):797.e1-5 - PubMed
- Eur J Cancer Prev. 2005 Jun;14(3):201-6 - PubMed
- J Epidemiol Biostat. 2001;6(5):387-92 - PubMed
- Dan Med Bull. 1999 Jun;46(3):263-8 - PubMed
- Clin Orthop Relat Res. 1982 May;(165):99-109 - PubMed
- Br J Cancer. 2005 Feb 14;92(3):594-6 - PubMed
- Int Orthop. 2001;25(6):401-3 - PubMed
- Arthroscopy. 2009 Jun;25(6):647-52 - PubMed
- Orthopedics. 2009 Mar;32(3):215 - PubMed
- Arthroscopy. 2009 Nov;25(11):1329-42 - PubMed
Publication Types