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Gross ND, Ganly I, Patel SG, et al. Results of anterior skull base surgery in pediatric and young adult patients. Skull Base. 2010;20(2):75-81doi: 10.1055/s-0029-1238215.
Gross, N. D., Ganly, I., Patel, S. G., Bilsky, M. H., Shah, J. P., & Kraus, D. H. (2010). Results of anterior skull base surgery in pediatric and young adult patients. Skull base : official journal of North American Skull Base Society ... [et al.], 20(2), 75-81. https://doi.org/10.1055/s-0029-1238215
Gross, Neil D, et al. "Results of anterior skull base surgery in pediatric and young adult patients." Skull base : official journal of North American Skull Base Society ... [et al.] vol. 20,2 (2010): 75-81. doi: https://doi.org/10.1055/s-0029-1238215
Gross ND, Ganly I, Patel SG, Bilsky MH, Shah JP, Kraus DH. Results of anterior skull base surgery in pediatric and young adult patients. Skull Base. 2010 Mar;20(2):75-81. doi: 10.1055/s-0029-1238215. PMID: 20808531; PMCID: PMC2853072.
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Skull Base. 2010 Mar;20(2):75-81. doi: 10.1055/s-0029-1238215.

Results of anterior skull base surgery in pediatric and young adult patients.

Skull base : official journal of North American Skull Base Society ... [et al.]

Neil D Gross, Ian Ganly, Snehal G Patel, Mark H Bilsky, Jatin P Shah, Dennis H Kraus

Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon.

PMID: 20808531 PMCID: PMC2853072 DOI: 10.1055/s-0029-1238215

Abstract

We sought to better define the results of anterior skull base surgery in pediatric and young adult patients. We performed a single-institution, retrospective cohort study in a tertiary-care academic cancer center. Between 1973 and 2005, 234 patients underwent anterior skull base surgery at Memorial Sloan-Kettering Cancer Center. Of these, 19 patients were <21 years of age. Surgical indications, findings, and complications were reviewed. Survival outcomes were analyzed using the Kaplan-Meier method and compared with patients >/=21 years old. Nineteen patients <21 years old underwent a total of 20 procedures for lesions of the anterior skull base. Sarcoma was the most common indication for surgery including 6 (32%) patients treated for radiation-induced malignancies. Minor complications were noted with 6 (30%) procedures. There were no major complications and no perioperative deaths. The difference in 3-year recurrence-free (68% versus 59%; p = 0.623) and overall survival (83% versus 66%; p = 0.309) compared with patients >/=21 years old did not reach statistical significance. Anterior skull base surgery is well tolerated in pediatric and young adult patients <21 years of age. Survival is comparable to older patients treated similarly and appears strongly influenced by histology.

Keywords: Craniofacial resection; complications; pediatric; skull base surgery; survival

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