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Reinwald S, Mayer LP, Hoyer PB, et al. A longitudinal study of the effect of genistein on bone in two different murine models of diminished estrogen-producing capacity. J Osteoporos. 2009;2010doi: 10.4061/2010/145170.
Reinwald, S., Mayer, L. P., Hoyer, P. B., Turner, C. H., Barnes, S., & Weaver, C. M. (2010). A longitudinal study of the effect of genistein on bone in two different murine models of diminished estrogen-producing capacity. Journal of osteoporosis, 2010. https://doi.org/10.4061/2010/145170
Reinwald, Susan, et al. "A longitudinal study of the effect of genistein on bone in two different murine models of diminished estrogen-producing capacity." Journal of osteoporosis vol. 2010 (2010). doi: https://doi.org/10.4061/2010/145170
Reinwald S, Mayer LP, Hoyer PB, Turner CH, Barnes S, Weaver CM. A longitudinal study of the effect of genistein on bone in two different murine models of diminished estrogen-producing capacity. J Osteoporos. 2010;2010. doi: 10.4061/2010/145170. Epub 2009 Oct 18. PMID: 20948578; PMCID: PMC2951124.
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J Osteoporos. 2010;2010. doi: 10.4061/2010/145170. Epub 2009 Oct 18.

A longitudinal study of the effect of genistein on bone in two different murine models of diminished estrogen-producing capacity.

Journal of osteoporosis

Susan Reinwald, Loretta P Mayer, Patricia B Hoyer, Charles H Turner, Stephen Barnes, Connie M Weaver

Affiliations

  1. Department of Foods & Nutrition, Purdue University, West Lafayette, IN 47907, USA.

PMID: 20948578 PMCID: PMC2951124 DOI: 10.4061/2010/145170

Abstract

This experiment was designed to assess the capacity of dietary genistein (GEN), to attenuate bone loss in ovariectomized (OVX) and ovary-intact VCD-treated mice. Pretreatment of mice with 4-vinylcyclohexene diepoxide (VCD) gradually and selectively destroys ovarian follicles whilst leaving ovarian androgen-producing cells largely intact. VCD induces a perimenopause-like condition prior to the onset of reproductive acyclicity. Sixteen-week-old C57BL/6J mice were randomized to five treatment groups: sham(SHM), OVX, SHM + VCD, OVX + GEN, and SHM + VCD + GEN. In vivo, blood samples were drawn for hormone and isoflavone analyses, estrous cycles were monitored, and X-ray imaging was performed to assess changes in bone parameters. Following sacrifice, ovaries were assessed histologically, bone microarchitecture was evaluated via microcomputed tomography, and bone mechanical properties were measured. Some effects of GEN were observed in OVX mice, but GEN effects were not able to be evaluated in VCD-treated mice due to the subtle diminution of bone during the 4 months of this experiment.

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