Display options
Cite
Hooli BV, Tanzi RE. A current view of Alzheimer's disease. F1000 Biol Rep. 2009;1:54doi: 10.3410/B1-54.
Hooli, B. V., & Tanzi, R. E. (2009). A current view of Alzheimer's disease. F1000 biology reports, 154. https://doi.org/10.3410/B1-54
Hooli, Basavaraj V, and Tanzi, Rudolph E. "A current view of Alzheimer's disease." F1000 biology reports vol. 1 (2009): 54. doi: https://doi.org/10.3410/B1-54
Hooli BV, Tanzi RE. A current view of Alzheimer's disease. F1000 Biol Rep. 2009 Jul 08;1:54. doi: 10.3410/B1-54. PMID: 20948630; PMCID: PMC2948255.
Copy Download .nbib Format: NLM
Share it on

F1000 Biol Rep. 2009 Jul 08;1:54. doi: 10.3410/B1-54.

A current view of Alzheimer's disease.

F1000 biology reports

Basavaraj V Hooli, Rudolph E Tanzi

Affiliations

  1. Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital 114 16th Street, Charlestown, MA 02129 USA.

PMID: 20948630 PMCID: PMC2948255 DOI: 10.3410/B1-54

Abstract

Several genes that influence susceptibility to Alzheimer's disease (AD) have been known for over two decades. Recent advances have elucidated novel candidate genes and the pathogenetic mechanisms underlying neurodegeneration in AD. Here, we summarize what we have learned from studies of the known AD genes with regard to the causes of AD and emerging therapies. We also review key recent discoveries that have enhanced our understanding of the etiology and pathogenesis of this devastating disease, based on new investigations into the genes and molecular mechanisms underlying AD.

References

  1. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5161-6 - PubMed
  2. Am J Hum Genet. 2008 Nov;83(5):623-32 - PubMed
  3. Behav Brain Res. 2008 Sep 1;192(1):106-13 - PubMed
  4. N Engl J Med. 2008 Feb 14;358(7):667-75 - PubMed
  5. Nature. 2009 Feb 26;457(7233):1128-32 - PubMed
  6. Neuron. 2006 Dec 7;52(5):831-43 - PubMed
  7. Am J Hum Genet. 2009 Jan;84(1):35-43 - PubMed
  8. Neurotherapeutics. 2008 Jul;5(3):421-32 - PubMed
  9. Nat Med. 2008 Aug;14(8):837-42 - PubMed
  10. Nature. 2002 Apr 4;416(6880):535-9 - PubMed
  11. Cell. 2005 Feb 25;120(4):545-55 - PubMed
  12. Mol Psychiatry. 2010 Jul;15(7):756-66 - PubMed
  13. Nutr Rev. 2007 Dec;65(12 Pt 2):S239-43 - PubMed
  14. Nat Genet. 2009 Feb;41(2):192-8 - PubMed
  15. J Neurosci. 2007 Oct 31;27(44):11832-7 - PubMed
  16. J Neurosci Res. 2009 Jun;87(8):1729-36 - PubMed
  17. Nature. 2008 Sep 11;455(7210):232-6 - PubMed
  18. Nat Genet. 2007 Jan;39(1):17-23 - PubMed
  19. Nat Neurosci. 2005 Aug;8(8):977-9 - PubMed
  20. J Neurosci. 2007 Jan 24;27(4):796-807 - PubMed

Publication Types