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Spicuglia S, Zacarias-Cabeza J, Pekowska A, et al. Epigenetic regulation of antigen receptor gene rearrangement. F1000 Biol Rep. 2010;2doi: 10.3410/B2-23.
Spicuglia, S., Zacarias-Cabeza, J., Pekowska, A., & Ferrier, P. (2010). Epigenetic regulation of antigen receptor gene rearrangement. F1000 biology reports, 2. https://doi.org/10.3410/B2-23
Spicuglia, Salvatore, et al. "Epigenetic regulation of antigen receptor gene rearrangement." F1000 biology reports vol. 2 (2010). doi: https://doi.org/10.3410/B2-23
Spicuglia S, Zacarias-Cabeza J, Pekowska A, Ferrier P. Epigenetic regulation of antigen receptor gene rearrangement. F1000 Biol Rep. 2010 Mar 25;2. doi: 10.3410/B2-23. PMID: 20948810; PMCID: PMC2948343.
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F1000 Biol Rep. 2010 Mar 25;2. doi: 10.3410/B2-23.

Epigenetic regulation of antigen receptor gene rearrangement.

F1000 biology reports

Salvatore Spicuglia, Joaquin Zacarias-Cabeza, Aleksandra Pekowska, Pierre Ferrier

PMID: 20948810 PMCID: PMC2948343 DOI: 10.3410/B2-23

Abstract

V(D)J recombination assembles antigen-specific immunoglobulin and T-cell receptor variable region genes from germline V, D, and J segments during lymphocyte development. Regulation of this site-specific DNA rearrangement process occurs with respect to the cell type and stage of differentiation, order of locus recombination, and allele usage. Many of these controls are mediated via the modulation of gene accessibility to the V(D)J recombinase. Here, we summarise recent advances regarding the impact of nuclear organisation and epigenetic-based mechanisms on the regulation of V(D)J recombination.

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