Display options
Cite
Johannsen TH, Ripa CP, Carlsen E, et al. Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. Int J Pediatr Endocrinol. 2010;2010:784297doi: 10.1155/2010/784297.
Johannsen, T. H., Ripa, C. P., Carlsen, E., Starup, J., Nielsen, O. H., Schwartz, M., Drzewiecki, K. T., Mortensen, E. L., & Main, K. M. (2010). Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. International journal of pediatric endocrinology, 2010784297. https://doi.org/10.1155/2010/784297
Johannsen, T H, et al. "Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency." International journal of pediatric endocrinology vol. 2010 (2010): 784297. doi: https://doi.org/10.1155/2010/784297
Johannsen TH, Ripa CP, Carlsen E, Starup J, Nielsen OH, Schwartz M, Drzewiecki KT, Mortensen EL, Main KM. Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. Int J Pediatr Endocrinol. 2010;2010:784297. doi: 10.1155/2010/784297. Epub 2010 Oct 20. PMID: 20981283; PMCID: PMC2963122.
Copy Download .nbib Format: NLM
Share it on

Int J Pediatr Endocrinol. 2010;2010:784297. doi: 10.1155/2010/784297. Epub 2010 Oct 20.

Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency.

International journal of pediatric endocrinology

T H Johannsen, C P L Ripa, E Carlsen, J Starup, O H Nielsen, M Schwartz, K T Drzewiecki, E L Mortensen, K M Main

Affiliations

  1. University Department of Growth and Reproduction, GR-5064, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.

PMID: 20981283 PMCID: PMC2963122 DOI: 10.1155/2010/784297

Abstract

Background. Our knowledge on long-term outcome in CAH remains incomplete. Methods. In a prospective study (33 CAH patients, 33 age-matched controls), reproductive outcomes, self-rating of genital appearance and function, and sexuality were correlated to degree of initial virilisation, genotype, and surgery. Results. Patients had larger median clitoral lengths (10.0 mm [range 2-30] versus 3.5 [2-8], P < .001), shorter vaginal length (121 mm [100-155] versus 128 [112-153], P = .12), lower uterine volumes (29.1 ml [7.5-56.7] versus 47.4 [15.9-177.5], P = .009), and higher ovarian volumes (4.4 ml [1.3-10.8] versus 2.8 [0.6-10.8], P = .09) than controls. Satisfaction with genital appearance was lower and negatively correlated to degree of initial virilisation (r(s) = ≤-0.39, P ≤ .05). More patients had never had intercourse (P = .001), and age at 1st intercourse was higher (18 yrs versus 16 yrs, P = .02). Conclusion. Despite overall acceptable cosmetic results, reproductive outcomes were suboptimal, supporting that multidisciplinary teams should be involved in adult follow up of CAH patients.

References

  1. J Clin Endocrinol Metab. 2006 Apr;91(4):1376-81 - PubMed
  2. N Engl J Med. 1998 Sep 17;339(12):853-4 - PubMed
  3. J Clin Endocrinol Metab. 2007 Apr;92(4):1391-6 - PubMed
  4. J Clin Endocrinol Metab. 2001 Jul;86(7):3070-8 - PubMed
  5. Pediatrics. 2002 Sep;110(3):e31 - PubMed
  6. Pediatrics. 2006 Jan;117(1):e98-105 - PubMed
  7. J Clin Endocrinol Metab. 2001 Dec;86(12):5721-8 - PubMed
  8. N Engl J Med. 1995 Sep 28;333(13):853-61 - PubMed
  9. Obes Res. 1998 Sep;6 Suppl 2:51S-209S - PubMed
  10. Horm Res. 2001;56(1-2):3-11 - PubMed
  11. Fertil Steril. 1994 Oct;62(4):738-43 - PubMed
  12. J Clin Endocrinol Metab. 1994 May;78(5):1145-52 - PubMed
  13. J Ultrasound Med. 1999 Apr;18(4):271-6 - PubMed
  14. J Clin Endocrinol Metab. 1994 Nov;79(5):1328-33 - PubMed
  15. Am J Pathol. 1962 May;40:587-98 - PubMed
  16. J Clin Endocrinol Metab. 1961 Nov;21:1440-7 - PubMed
  17. Lancet. 2003 Apr 12;361(9365):1252-7 - PubMed
  18. Best Pract Res Clin Endocrinol Metab. 2009 Apr;23(2):193-208 - PubMed
  19. J Clin Endocrinol Metab. 2002 May;87(5):2114-20 - PubMed
  20. J Clin Endocrinol Metab. 1992 Dec;75(6):1421-4 - PubMed
  21. Clin Endocrinol (Oxf). 1990 Oct;33(4):501-10 - PubMed
  22. Lancet. 2001 Jul 14;358(9276):124-5 - PubMed
  23. J Clin Endocrinol Metab. 2008 Feb;93(2):380-6 - PubMed
  24. Eur Radiol. 2004 Oct;14(10):1802-6 - PubMed
  25. BJU Int. 1999 Apr;83 Suppl 3:39-50 - PubMed
  26. Psychoneuroendocrinology. 1992 May-Jul;17(2-3):153-70 - PubMed
  27. Eur J Endocrinol. 2006 Dec;155(6):877-85 - PubMed
  28. Obstet Gynecol Surv. 2003 Apr;58(4):275-84 - PubMed
  29. Am J Obstet Gynecol. 1981 Aug 1;140(7):815-30 - PubMed
  30. Eur Urol. 1993;24(2):231-8 - PubMed
  31. Am J Surg Pathol. 1988 Jul;12(7):503-13 - PubMed
  32. Ann Surg. 1992 Jun;215(6):644-53 - PubMed
  33. Lancet. 2003 Apr 12;361(9365):1236-7 - PubMed
  34. Clin Endocrinol (Oxf). 1985 Oct;23(4):385-93 - PubMed

Publication Types