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Lakmichi H, Bakhtaoui FZ, Gadhi CA, et al. Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents. Evid Based Complement Alternat Med. 2010;2011doi: 10.1155/2011/317090.
Lakmichi, H., Bakhtaoui, F. Z., Gadhi, C. A., Ezoubeiri, A., El Jahiri, Y., El Mansouri, A., Zrara, I., & Loutfi, K. (2011). Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents. Evidence-based complementary and alternative medicine : eCAM, 2011. https://doi.org/10.1155/2011/317090
Lakmichi, Hind, et al. "Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents." Evidence-based complementary and alternative medicine : eCAM vol. 2011 (2011). doi: https://doi.org/10.1155/2011/317090
Lakmichi H, Bakhtaoui FZ, Gadhi CA, Ezoubeiri A, El Jahiri Y, El Mansouri A, Zrara I, Loutfi K. Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents. Evid Based Complement Alternat Med. 2011;2011. doi: 10.1155/2011/317090. Epub 2010 Sep 07. PMID: 20953424; PMCID: PMC2952298.
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Evid Based Complement Alternat Med. 2011;2011. doi: 10.1155/2011/317090. Epub 2010 Sep 07.

Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents.

Evidence-based complementary and alternative medicine : eCAM

Hind Lakmichi, Fatima Zahra Bakhtaoui, Chemseddoha A Gadhi, Aicha Ezoubeiri, Younes El Jahiri, Abdellah El Mansouri, Ibtissam Zrara, Kenza Loutfi

Affiliations

  1. Unit of Phytochemistry and Pharmacology of Aromatic and Medicinal Plants, Laboratory of Biotechnology, Protection and Valorization of Plant Resources, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech 40000, Morocco.

PMID: 20953424 PMCID: PMC2952298 DOI: 10.1155/2011/317090

Abstract

Corrigiola telephiifolia Pourr. (Caryophyllaceae) is a Moroccan medicinal plant. Despite its popular usage, no study has been published concerning its toxicological profile. The acute toxicity of C. telephiifolia root extract was evaluated by giving it orally to mice at single doses of 5000, 10000, and 14000 mg/kg bodyweight. The extract was also administered at doses of 5, 70, and 2000 mg/kg bodyweight per day to rats for a forty-day toxicity study. No mortality or signs of toxicity were observed in the acute study. In the forty-day study in rats, the extract at 5 mg/kg/day showed no toxicological effects in either sex. At 70 mg/kg/day, the treated group differed from the control only by a significant decrease in serum concentrations of sodium and chloride ions (P < .05). At the dose of 2000 mg/kg/day, the extract significantly increased the serum concentrations of creatinine, alkaline phosphatase, gamma-glutamyltransferase and phosphorus (P < .05) all suggestive of functional nephrotoxicity and hepatotoxicity. The relative bodyweight of both sexes decreased at the dose of 2000 mg/kg/day, with a fast recovery for males. Histological examination did not reveal any treatment-related effects. In conclusion, Corrigiola extract appears safe at the doses used ethno-medicinally. Much higher doses pose toxicological risks.

References

  1. J Clin Oncol. 2005 Sep 10;23(26):6439-40 - PubMed
  2. Z Naturforsch C J Biosci. 2004 May-Jun;59(5-6):432-6 - PubMed
  3. Evid Based Complement Alternat Med. 2006 Dec;3(4):433-9 - PubMed
  4. Acta Histochem. 2000 Feb;102(1):21-35 - PubMed
  5. Lancet. 1993 Feb 13;341(8842):387-91 - PubMed
  6. Lancet. 2000 Jan 8;355(9198):134-8 - PubMed
  7. Phytomedicine. 2005 Jan;12(1-2):138-42 - PubMed
  8. Toxicology. 2008 Mar 20;245(3):194-205 - PubMed
  9. Mol Pharmacol. 2009 Aug;76(2):215-28 - PubMed
  10. CMAJ. 2005 Feb 1;172(3):367-79 - PubMed
  11. Atherosclerosis. 2003 Apr;167(2):367 - PubMed
  12. Top HIV Med. 2005 Jun-Jul;13(2):79-83 - PubMed
  13. Arch Intern Med. 1998 Nov 9;158(20):2200-11 - PubMed
  14. Evid Based Complement Alternat Med. 2004 Jun 1;1(1):1-4 - PubMed
  15. Br J Nutr. 2002 Dec;88(6):587-605 - PubMed
  16. Clin Pharmacol Ther. 2004 Jan;75(1):13-33 - PubMed
  17. Hepatology. 2003 Oct;38(4):978-88 - PubMed
  18. Phytomedicine. 2004;11(4):352-60 - PubMed
  19. Evid Based Complement Alternat Med. 2004 Sep 1;1(2):113-118 - PubMed
  20. Phytother Res. 2002 Mar;16(2):127-32 - PubMed
  21. J Ethnopharmacol. 2003 Sep;88(1):15-8 - PubMed
  22. Evid Based Complement Alternat Med. 2009 Jun;6(2):195-201 - PubMed
  23. Jpn J Pharmacol. 1997 Dec;75(4):451-4 - PubMed
  24. J Ethnopharmacol. 2004 Oct;94(2-3):219-43 - PubMed
  25. Int J Biochem Cell Biol. 2002 Dec;34(12):1586-93 - PubMed
  26. Evid Based Complement Alternat Med. 2009 Dec;6(4):423-7 - PubMed
  27. Life Sci. 2006 Apr 25;78(22):2595-600 - PubMed
  28. Evid Based Complement Alternat Med. 2008 Sep;5(3):281-7 - PubMed
  29. Am J Health Syst Pharm. 1997 Mar 15;54(6):692-3 - PubMed
  30. J Ethnopharmacol. 2006 Oct 11;107(3):361-4 - PubMed
  31. Phytother Res. 1999 Mar;13(2):128-32 - PubMed
  32. Curr Drug Discov Technol. 2007 Jun;4(1):59-68 - PubMed
  33. Phytother Res. 2004 Mar;18(3):191-4 - PubMed
  34. Phytomedicine. 1996 Mar;2(4):363-86 - PubMed
  35. Toxicology. 2008 Mar 20;245(3):182-93 - PubMed
  36. J Ethnopharmacol. 2004 Oct;94(2-3):205-17 - PubMed
  37. Drugs Aging. 1999 Dec;15(6):423-8 - PubMed
  38. Int J Obes. 1986;10(4):293-302 - PubMed
  39. Zhongguo Zhong Yao Za Zhi. 2006 Jun;31(11):910-3 - PubMed
  40. Prim Care. 1996 Sep;23(3):551-60 - PubMed
  41. Clin Pharmacol Ther. 1999 Oct;66(4):338-45 - PubMed
  42. J Ethnopharmacol. 2002 Dec;83(3):209-17 - PubMed
  43. Am J Med. 1998 Feb;104(2):170-8 - PubMed

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