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Mol Cell. 2010 Oct 08;40(1):5-7. doi: 10.1016/j.molcel.2010.09.016.

The special delivery of a tail-anchored protein: why it pays to use a dedicated courier.

Molecular cell

Jeffrey L Brodsky

Affiliations

  1. Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. [email protected]

PMID: 20932470 PMCID: PMC2953543 DOI: 10.1016/j.molcel.2010.09.016

Abstract

The membrane-spanning C-terminal regions in tail-anchored proteins must be recognized and delivered posttranslationally to the endoplasmic reticulum or mitochondrial membrane. A paper in this issue of Molecular Cell (Wang et al., 2010) and another recent report (Mariappan et al., 2010) delineate early steps in this pathway.

Copyright © 2010 Elsevier Inc. All rights reserved.

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