Mol Cell. 2010 Oct 08;40(1):5-7. doi: 10.1016/j.molcel.2010.09.016.
Molecular cell
Jeffrey L Brodsky
PMID: 20932470 PMCID: PMC2953543 DOI: 10.1016/j.molcel.2010.09.016
The membrane-spanning C-terminal regions in tail-anchored proteins must be recognized and delivered posttranslationally to the endoplasmic reticulum or mitochondrial membrane. A paper in this issue of Molecular Cell (Wang et al., 2010) and another recent report (Mariappan et al., 2010) delineate early steps in this pathway.
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