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Barroso-Chinea P, Bezard E. Basal Ganglia circuits underlying the pathophysiology of levodopa-induced dyskinesia. Front Neuroanat. 2010;4doi: 10.3389/fnana.2010.00131.
Barroso-Chinea, P., & Bezard, E. (2010). Basal Ganglia circuits underlying the pathophysiology of levodopa-induced dyskinesia. Frontiers in neuroanatomy, 4. https://doi.org/10.3389/fnana.2010.00131
Barroso-Chinea, Pedro, and Bezard, Erwan. "Basal Ganglia circuits underlying the pathophysiology of levodopa-induced dyskinesia." Frontiers in neuroanatomy vol. 4 (2010). doi: https://doi.org/10.3389/fnana.2010.00131
Barroso-Chinea P, Bezard E. Basal Ganglia circuits underlying the pathophysiology of levodopa-induced dyskinesia. Front Neuroanat. 2010 Sep 14;4. doi: 10.3389/fnana.2010.00131. eCollection 2010. PMID: 20890450; PMCID: PMC2947938.
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Front Neuroanat. 2010 Sep 14;4. doi: 10.3389/fnana.2010.00131. eCollection 2010.

Basal Ganglia circuits underlying the pathophysiology of levodopa-induced dyskinesia.

Frontiers in neuroanatomy

Pedro Barroso-Chinea, Erwan Bezard

Affiliations

  1. Centre National de la Recherche Scientifique UMR 5227, Bordeaux Institute of Neuroscience, Université Victor-Segalen Bordeaux 2 Bordeaux, France.

PMID: 20890450 PMCID: PMC2947938 DOI: 10.3389/fnana.2010.00131

Abstract

Involuntary movements or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson's disease. Dyskinesia is, ultimately, experienced by the vast majority of the patients. Despite the importance of this problem, little was known about the cause of dyskinesia, a situation that has dramatically evolved in the last few years with a focus upon the molecular and signaling changes induced by chronic levodopa treatment. Departing from this, we here review the progress made in functional anatomy and neuroimaging that have had a tremendous impact on our understanding of the anatomo-functional organization of the basal ganglia in Parkinsonism and dyskinetic states, notably the demonstration that dyskinesia are linked to a pathological processing of limbic and cognitive information.

Keywords: Parkinson's disease; abnormal involuntary movements; basal ganglia; levodopa

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