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Lee JA, Ku Y, Rhyu IC, et al. Effects of fibrin-binding oligopeptide on osteopromotion in rabbit calvarial defects. J Periodontal Implant Sci. 2010;40(5):211-9doi: 10.5051/jpis.2010.40.5.211.
Lee, J. A., Ku, Y., Rhyu, I. C., Chung, C. P., & Park, Y. J. (2010). Effects of fibrin-binding oligopeptide on osteopromotion in rabbit calvarial defects. Journal of periodontal & implant science, 40(5), 211-9. https://doi.org/10.5051/jpis.2010.40.5.211
Lee, Ju-A, et al. "Effects of fibrin-binding oligopeptide on osteopromotion in rabbit calvarial defects." Journal of periodontal & implant science vol. 40,5 (2010): 211-9. doi: https://doi.org/10.5051/jpis.2010.40.5.211
Lee JA, Ku Y, Rhyu IC, Chung CP, Park YJ. Effects of fibrin-binding oligopeptide on osteopromotion in rabbit calvarial defects. J Periodontal Implant Sci. 2010 Oct;40(5):211-9. doi: 10.5051/jpis.2010.40.5.211. Epub 2010 Oct 31. PMID: 21072217; PMCID: PMC2967808.
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J Periodontal Implant Sci. 2010 Oct;40(5):211-9. doi: 10.5051/jpis.2010.40.5.211. Epub 2010 Oct 31.

Effects of fibrin-binding oligopeptide on osteopromotion in rabbit calvarial defects.

Journal of periodontal & implant science

Ju-A Lee, Young Ku, In-Chul Rhyu, Chong-Pyoung Chung, Yoon-Jeong Park

Affiliations

  1. Department of Periodontology and Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea.

PMID: 21072217 PMCID: PMC2967808 DOI: 10.5051/jpis.2010.40.5.211

Abstract

PURPOSE: Fibronectin (FN) has been shown to stimulate bone regeneration in animal models. The aim of this study was to evaluate the capacity of bovine bone mineral coated with synthetic oligopeptides to enhance bone regeneration in rabbit calvarial defects.

METHODS: Oligopeptides including fibrin-binding sequences of FN repeats were synthesized on the basis of primary and tertiary human plasma FN structures. Peptide coated and uncoated bone minerals were implanted into 10 mm calvarial defects in New Zealand white rabbits, and the animals were sacrificed at 4 or 8 weeks after surgery. After specimens were prepared, histologic examination and histomorphometric analysis were performed.

RESULTS: At 4 weeks after surgery, the uncoated groups showed a limited amount of osteoid formation at the periphery of the defect and the oligopeptide coated groups showed more osteoid formation and new bone formation in the center of the defect as well as at the periphery. At 8 weeks, both sites showed increased new bone formation. However, the difference between the two sites had reduced.

CONCLUSIONS: Fibrin-binding synthetic oligopeptide derived from FN on deproteinized bovine bone enhanced new bone formation in rabbit calvarial defects at the early healing stage. This result suggests that these oligopeptides can be beneficial in reconstructing oral and maxillofacial deformities or in regenerating osseous bone defects.

Keywords: Fibrin; Fibronectins; Oligopeptides

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