Display options
Cite
Pachman DR, Jones JM, Loprinzi CL. Management of menopause-associated vasomotor symptoms: Current treatment options, challenges and future directions. Int J Womens Health. 2010;2:123-35doi: 10.2147/ijwh.s7721.
Pachman, D. R., Jones, J. M., & Loprinzi, C. L. (2010). Management of menopause-associated vasomotor symptoms: Current treatment options, challenges and future directions. International journal of women's health, 2123-35. https://doi.org/10.2147/ijwh.s7721
Pachman, Deirdre R, et al. "Management of menopause-associated vasomotor symptoms: Current treatment options, challenges and future directions." International journal of women's health vol. 2 (2010): 123-35. doi: https://doi.org/10.2147/ijwh.s7721
Pachman DR, Jones JM, Loprinzi CL. Management of menopause-associated vasomotor symptoms: Current treatment options, challenges and future directions. Int J Womens Health. 2010 Aug 09;2:123-35. doi: 10.2147/ijwh.s7721. PMID: 21072305; PMCID: PMC2971731.
Copy Download .nbib Format: NLM
Share it on

Int J Womens Health. 2010 Aug 09;2:123-35. doi: 10.2147/ijwh.s7721.

Management of menopause-associated vasomotor symptoms: Current treatment options, challenges and future directions.

International journal of women's health

Deirdre R Pachman, Jason M Jones, Charles L Loprinzi

Affiliations

  1. Internal Medicine, Mayo Clinic, Rochester, MN, USA;

PMID: 21072305 PMCID: PMC2971731 DOI: 10.2147/ijwh.s7721

Abstract

Hot flashes are one of the most common and distressing symptoms associated with menopause, occurring in more than 75% of postmenopausal women. They are especially problematic in breast cancer patients since some breast cancer therapies can induce hot flashes. For mild hot flashes, it is proposed that behavioral modifications are the first step in management. Hormonal therapies, including estrogens and progestogens, are the most well known effective agents in relieving hot flashes; however, the safety of these agents is controversial. There is an increasing amount of literature on nonhormonal agents for the treatment of hot flashes. The most promising data regard newer antidepressant agents such as venlafaxine, which reduces hot flashes by about 60%. Gabapentin is another nonhormonal agent that is effective in reducing hot flashes. While many complimentary therapies, including phytoestrogens, black cohosh, and dehydroepiandrosterone, have been explored for the treatment of hot flashes; none can be recommended at this time. Furthermore, there is a lack of strong evidence to support exercise, yoga, or relaxation for the treatment of hot flashes. Paced respirations and hypnosis appear to be promising enough to warrant further investigation. Another promising nonpharmacological therapy, currently under investigation, involves a stellate ganglion block.

Keywords: hot flashes; menopause; therapy; vasomotor symptoms

References

  1. Lancet. 2000 Dec 16;356(9247):2059-63 - PubMed
  2. Ann N Y Acad Sci. 1990;592:52-86; discussion 123-33 - PubMed
  3. Maturitas. 2001 Jan 31;37(3):159-65 - PubMed
  4. J Pain Symptom Manage. 2002 Dec;24(6):603-7 - PubMed
  5. J Clin Endocrinol Metab. 1998 Jul;83(7):2223-35 - PubMed
  6. Curr Med Res Opin. 1984;8(10):696-700 - PubMed
  7. Br J Prev Soc Med. 1974 May;28(2):108-15 - PubMed
  8. Br J Clin Pharmacol. 1996 Feb;41(2):149-56 - PubMed
  9. Menopause. 2009 Nov-Dec;16(6):1156-66 - PubMed
  10. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD006108 - PubMed
  11. J Consult Clin Psychol. 1984 Dec;52(6):1072-9 - PubMed
  12. Med Hypotheses. 2007;69(4):758-63 - PubMed
  13. Obstet Gynecol. 2005 Jan;105(1):161-6 - PubMed
  14. Psychol Bull. 1982 Mar;91(2):215-43 - PubMed
  15. Support Cancer Ther. 2006 Jan 1;3(2):91-7 - PubMed
  16. Obstet Gynecol. 1975 Aug;46(2):165-8 - PubMed
  17. J Clin Oncol. 1998 Feb;16(2):495-500 - PubMed
  18. Menopause. 2004 Jan-Feb;11(1):11-33 - PubMed
  19. Support Care Cancer. 2011 Jul;19(7):941-7 - PubMed
  20. Gynecol Obstet Invest. 1992;34(2):102-4 - PubMed
  21. Menopause. 2005 Jan-Feb;12(1):18-26 - PubMed
  22. Fertil Steril. 1997 Dec;68(6):981-6 - PubMed
  23. Lancet. 2003 Aug 9;362(9382):419-27 - PubMed
  24. Menopause. 2008 Jan-Feb;15(1):193-202 - PubMed
  25. JAMA. 2002 Jul 17;288(3):321-33 - PubMed
  26. Oncol Nurs Forum. 1999 Sep;26(8):1311-7 - PubMed
  27. Am J Med. 2005 Dec 19;118 Suppl 12B:98-108 - PubMed
  28. J Clin Oncol. 1998 Jul;16(7):2377-81 - PubMed
  29. Cancer. 1998 May 1;82(9):1784-8 - PubMed
  30. Climacteric. 2007 Jun;10(3):197-214 - PubMed
  31. Lancet. 2005 Sep 3-9;366(9488):818-24 - PubMed
  32. Ann Oncol. 2000 Jan;11(1):17-22 - PubMed
  33. Menopause. 2008 Jul-Aug;15(4 Pt 1):584-602 - PubMed
  34. J Support Oncol. 2003 May-Jun;1(1):47-51 - PubMed
  35. J Clin Oncol. 2002 Mar 15;20(6):1578-83 - PubMed
  36. Am J Obstet Gynecol. 1999 Jul;181(1):66-70 - PubMed
  37. J Clin Endocrinol Metab. 2002 Aug;87(8):3760-7 - PubMed
  38. Obstet Gynecol. 1982 Nov;60(5):583-6 - PubMed
  39. Obstet Gynecol. 1999 Aug;94(2):225-8 - PubMed
  40. Menopause. 2009 Jan-Feb;16(1):132-40 - PubMed
  41. Lancet Oncol. 2001 Apr;2(4):199-204 - PubMed
  42. Clin Sci (Lond). 2007 May;112(10):517-25 - PubMed
  43. Obstet Gynecol. 2003 Feb;101(2):337-45 - PubMed
  44. JAMA. 2003 Jul 9;290(2):207-14 - PubMed
  45. J Clin Oncol. 2008 Apr 1;26(10):1650-6 - PubMed
  46. Arch Intern Med. 1991 Sep;151(9):1842-7 - PubMed
  47. Pain Physician. 2000 Jul;3(3):294-304 - PubMed
  48. Obstet Gynecol. 2000 May;95(5):726-31 - PubMed
  49. J Clin Endocrinol Metab. 1999 Dec;84(12):4559-65 - PubMed
  50. J Womens Health (Larchmt). 2005 Oct;14(8):737-41 - PubMed
  51. Menopause. 2005 Nov-Dec;12(6):734-40 - PubMed
  52. J Am Med Womens Assoc (1972). 1999 Fall;54(4):181-3 - PubMed
  53. Ann Oncol. 2002 Jun;13(6):883-8 - PubMed
  54. J Clin Oncol. 2008 Nov 1;26(31):5022-6 - PubMed
  55. N Engl J Med. 1994 Aug 11;331(6):347-52 - PubMed
  56. Am J Obstet Gynecol. 2009 Mar;200(3):238.e1-238.e10 - PubMed
  57. Maturitas. 2004 Aug 30;48 Suppl 1:S30-40 - PubMed
  58. BMJ. 1993 Oct 2;307(6908):836-40 - PubMed
  59. Clin Endocrinol (Oxf). 1985 Mar;22(3):293-312 - PubMed
  60. J Natl Cancer Inst. 2005 Jan 5;97(1):30-9 - PubMed
  61. Breast J. 2003 Sep-Oct;9(5):431-8 - PubMed
  62. Mayo Clin Proc. 2008 Jan;83(1):23-34 - PubMed
  63. J Clin Oncol. 1994 Jan;12(1):155-8 - PubMed
  64. J Palliat Med. 2005 Oct;8(5):924-30 - PubMed
  65. Ann Intern Med. 2002 Nov 19;137(10):805-13 - PubMed
  66. J Soc Integr Oncol. 2007 Summer;5(3):106-12 - PubMed
  67. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD002978 - PubMed
  68. Ann Intern Med. 2000 May 16;132(10):788-93 - PubMed
  69. Menopause. 2001 Jan-Feb;8(1):17-26 - PubMed
  70. Mayo Clin Proc. 2002 Nov;77(11):1207-18 - PubMed
  71. Menopause. 2003 Mar-Apr;10(2):113-32 - PubMed
  72. Maturitas. 1994 Oct;19(3):155-6 - PubMed
  73. Maturitas. 1987 Nov;9(3):227-34 - PubMed
  74. BMJ. 1988 Nov 5;297(6657):1169-72 - PubMed
  75. JAMA. 2006 May 3;295(17):2057-71 - PubMed
  76. Obstet Gynecol. 1969 Jun;33(6):795-9 - PubMed
  77. J Clin Oncol. 2010 Feb 1;28(4):641-7 - PubMed
  78. Ann N Y Acad Sci. 1977 Oct 7;296:175-93 - PubMed
  79. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD001395 - PubMed
  80. Fertil Steril. 2000 Jul;74(1):20-3 - PubMed
  81. BMJ. 1994 Feb 19;308(6927):501-3 - PubMed
  82. Arch Gynecol. 1979;227(4):341-7 - PubMed
  83. Expert Opin Drug Saf. 2006 Sep;5(5):695-701 - PubMed
  84. Obstet Gynecol. 1984 Jan;63(1):1-5 - PubMed
  85. N Engl J Med. 2008 Aug 14;359(7):697-708 - PubMed
  86. Br Med J. 1974 Mar 9;1(5905):409-12 - PubMed
  87. J Abnorm Psychol. 1973 Aug;82(1):153-8 - PubMed
  88. J Clin Oncol. 1995 Nov;13(11):2737-44 - PubMed
  89. Maturitas. 2006 Oct 20;55(3):203-11 - PubMed
  90. J Pain Symptom Manage. 2008 Apr;35(4):397-405 - PubMed
  91. Lancet Oncol. 2008 Jun;9(6):523-32 - PubMed
  92. Maturitas. 2000 Oct 31;36(3):155-64 - PubMed
  93. Obstet Gynecol. 2008 Jan;111(1):77-87 - PubMed
  94. J Clin Endocrinol Metab. 1984 Jun;58(6):1158-60 - PubMed
  95. Menopause. 2009 Sep-Oct;16(5):1065-73 - PubMed
  96. Neurology. 2000 Jun 13;54(11):2161-3 - PubMed
  97. Int J Clin Pharmacol Res. 1999;19(3):89-99 - PubMed
  98. Support Care Cancer. 2009 Oct;17(10):1301-9 - PubMed
  99. Am J Obstet Gynecol. 1980 Sep 1;138(1):99-104 - PubMed
  100. Maturitas. 2008 May 20;60(1):42-9 - PubMed
  101. Menopause. 2006 Jul-Aug;13(4):631-42 - PubMed
  102. J Clin Oncol. 2006 Mar 20;24(9):1409-14 - PubMed
  103. Am J Hum Biol. 2001 Jul-Aug;13(4):453-64 - PubMed
  104. Lancet Oncol. 2009 Feb;10(2):103-4 - PubMed
  105. Drugs Aging. 2001;18(8):597-606 - PubMed
  106. Biofeedback Self Regul. 1993 Mar;18(1):1-22 - PubMed
  107. Menopause. 2009 May-Jun;16(3):602-8 - PubMed
  108. Obstet Gynecol. 2006 Jul;108(1):41-8 - PubMed
  109. Br J Obstet Gynaecol. 1998 Aug;105(8):904-11 - PubMed
  110. Ann Intern Med. 2005 Jun 21;142(12 Pt 1):1003-13 - PubMed
  111. Mayo Clin Proc. 2002 Nov;77(11):1159-63 - PubMed
  112. Maturitas. 1998 Nov 16;30(3):295-305 - PubMed
  113. J Clin Oncol. 2009 Jun 10;27(17):2831-7 - PubMed
  114. Obstet Gynecol. 1988 Nov;72(5):688-92 - PubMed
  115. Obstet Gynecol. 2007 Oct;110(4):771-9 - PubMed
  116. J Clin Oncol. 2006 Jun 20;24(18):2836-41 - PubMed
  117. Menopause. 2006 Sep-Oct;13(5):760-9 - PubMed
  118. J Clin Psychol. 1992 May;48(3):388-93 - PubMed
  119. Climacteric. 2001 Jun;4(2):144-50 - PubMed
  120. Psychooncology. 2007 May;16(5):487-92 - PubMed
  121. Lancet Oncol. 2009 Feb;10(2):135-46 - PubMed
  122. Endocrinology. 2007 Mar;148(3):1376-83 - PubMed
  123. Menopause. 2008 Sep-Oct;15(5):862-70 - PubMed
  124. Am J Obstet Gynecol. 1992 Aug;167(2):436-9 - PubMed
  125. Expert Opin Investig Drugs. 2007 Dec;16(12):2005-20 - PubMed
  126. Gynecol Endocrinol. 2000 Oct;14(5):342-63 - PubMed
  127. Menopause. 2007 Mar-Apr;14(2):223-9 - PubMed
  128. Menopause. 2002 Mar-Apr;9(2):145-50 - PubMed
  129. Breast Cancer Res Treat. 2009 Jun;115(3):497-503 - PubMed
  130. J Clin Endocrinol Metab. 1949 Jan;9(1):89-94 - PubMed
  131. JAMA. 2000 Jan 26;283(4):485-91 - PubMed
  132. Am J Obstet Gynecol. 1988 May;158(5):1107-15 - PubMed
  133. JAMA. 2003 Jun 4;289(21):2827-34 - PubMed
  134. Menopause Int. 2009 Jun;15(2):63-9 - PubMed
  135. J Clin Oncol. 2010 Jul 10;28(20):3278-83 - PubMed
  136. J Clin Oncol. 2000 Mar;18(5):1068-74 - PubMed
  137. N Engl J Med. 2006 Nov 30;355(22):2338-47 - PubMed
  138. Maturitas. 2009 Jul 20;63(3):176-80 - PubMed
  139. Clin Cancer Res. 2004 Nov 15;10(22):7703-11 - PubMed
  140. J Clin Oncol. 2005 Oct 1;23(28):6919-30 - PubMed

Publication Types

Grant support