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J Med Case Rep. 2010 Oct 25;4:337. doi: 10.1186/1752-1947-4-337.

Hashimoto's encephalopathy presenting with neurocognitive symptoms: a case report.

Journal of medical case reports

Carlos Canelo-Aybar, David Loja-Oropeza, Jose Cuadra-Urteaga, Franco Romani-Romani

Affiliations

  1. Department of Medicine, Arzobispo Loayza Hospital, Lima, Peru. [email protected].

PMID: 20973943 PMCID: PMC2987955 DOI: 10.1186/1752-1947-4-337

Abstract

INTRODUCTION: Hashimoto's encephalopathy is a neurological disorder of unknown cause associated with thyroid autoimmunity. The disease occurs primarily in the fifth decade of life and may present in two types - a sudden vasculitic type or a progressive subacute type associated to cognitive dysfunction, confusion and memory loss.

CASE PRESENTATION: We report the case of a 62-year-old Hispanic woman, previously healthy, who developed a subacute onset of declining upper brain function. Serologic studies demonstrated high levels of antithyroid antibodies. Electroencephalographic and magnetic resonance image findings were consistent with Hashimoto's encephalopathy.

CONCLUSION: Hashimoto's encephalopathy is a diagnosis of exclusion. This unusual disorder is often under-recognized because of the multiple and protracted neurocognitive manifestations; therefore, it is important to be aware of the clinical manifestations to make a correct diagnosis.

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