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Zahavi M, Bornstein NM, Zahavi J, et al. Increased Thromboxane B(2) Generation and β-Thromboglobulin Release from Activated Platelets in Myotonic Dystrophy. Platelets. 1993;4(1):45-8doi: 10.3109/09537109309013195.
Zahavi, M., Bornstein, N. M., Zahavi, J., & Korczyn, A. D. (1993). Increased Thromboxane B(2) Generation and β-Thromboglobulin Release from Activated Platelets in Myotonic Dystrophy. Platelets, 4(1), 45-8. https://doi.org/10.3109/09537109309013195
Zahavi, M, et al. "Increased Thromboxane B(2) Generation and β-Thromboglobulin Release from Activated Platelets in Myotonic Dystrophy." Platelets vol. 4,1 (1993): 45-8. doi: https://doi.org/10.3109/09537109309013195
Zahavi M, Bornstein NM, Zahavi J, Korczyn AD. Increased Thromboxane B(2) Generation and β-Thromboglobulin Release from Activated Platelets in Myotonic Dystrophy. Platelets. 1993;4(1):45-8. doi: 10.3109/09537109309013195. PMID: 21043853.
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Platelets. 1993;4(1):45-8. doi: 10.3109/09537109309013195.

Increased Thromboxane B(2) Generation and β-Thromboglobulin Release from Activated Platelets in Myotonic Dystrophy.

Platelets

M Zahavi, N M Bornstein, J Zahavi, A D Korczyn

Affiliations

  1. Vascular Laboratory, Israel.

PMID: 21043853 DOI: 10.3109/09537109309013195

Abstract

Compared to normal controls, platelets from myotonic dystrophy (MyD) patients, released significantly more β-thromboglobulin (βTG) and generated more thromboxane B(2) (TXB(2)) when platelet aggregation was induced by ADP (1.5 μM) or epinephrine 1 μM. TXB(2) generation in MyD platelets at 1 and 3 min was positively correlated (p < 0.05) to platelet aggregation (PA). This suggests that, 1 min after the addition of the PA inducers, the platelets of MyD patients are already at the second (irreversible) phase of PA. Together with our previous data, these results may indicate hyperactivity of platelets caused by a membrane abnormality in MyD.

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