Display options
Cite
Al-Momen AK, Gader AM. Dipyridamole in the Management of Severe Heparin-associated Thrombocytopenia. Platelets. 1993;4(2):67-71doi: 10.3109/09537109309013198.
Al-Momen, A. K., & Gader, A. M. (1993). Dipyridamole in the Management of Severe Heparin-associated Thrombocytopenia. Platelets, 4(2), 67-71. https://doi.org/10.3109/09537109309013198
Al-Momen, A K, and Gader, A M. "Dipyridamole in the Management of Severe Heparin-associated Thrombocytopenia." Platelets vol. 4,2 (1993): 67-71. doi: https://doi.org/10.3109/09537109309013198
Al-Momen AK, Gader AM. Dipyridamole in the Management of Severe Heparin-associated Thrombocytopenia. Platelets. 1993;4(2):67-71. doi: 10.3109/09537109309013198. PMID: 21043885.
Copy Download .nbib Format: NLM
Share it on

Platelets. 1993;4(2):67-71. doi: 10.3109/09537109309013198.

Dipyridamole in the Management of Severe Heparin-associated Thrombocytopenia.

Platelets

A K Al-Momen, A M Gader

Affiliations

  1. Department of Medicine (38), College of Medicine, King Khalid University Hospital, P.O. Box 2925-11461, Riyadh, Saudi Arabia.

PMID: 21043885 DOI: 10.3109/09537109309013198

Abstract

Severe heparin-associated thrombocytopenia (SHAT) is a rare, life-threatening condition. The aim of this prospective pilot study was to determine the safety and efficacy of dipyridamole-heparin infusion (DHI) in the management of the condition. We studied 6 patients (4 males and 2 females) aged 28 to 80 years (mean 50.5±14.2) with deep venous thrombosis and/or pulmonary embolism who developed SHAT a few days following heparin therapy. Heparin-dependent platelet aggregating factor was demonstrated ex vivo in the plasma of 4 patients. 240-300 mg of dipyridamole/day (4 mg/kg/day) was mixed with heparin in the same bag and given as a continuous intravenous infusion. Anticoagulation was continued successfully along with significant platelet recovery over a few days. This regimen was without side-effects. We conclude that DHI may provide an effective therapy for patients with SHAT.

Publication Types