F1000 Biol Rep. 2010 Nov 11;2:80. doi: 10.3410/B2-80.
F1000 biology reports
Fred Dyda
PMID: 21170372 PMCID: PMC2998839 DOI: 10.3410/B2-80
Despite the recent substantial technological developments in X-ray crystallography, solving and refining structures at low resolutions remain substantial challenges. Many macromolecular crystals, especially those of large molecules or multicomponent assemblies, diffract X-rays to resolutions that are worse than 3.5Å. This report summarizes several recent advances aiding low resolution crystallographic work.