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Barbeau EJ, Didic M, Felician O, et al. Pure progressive amnesia: An atypical amnestic syndrome?. Cogn Neuropsychol. 2006;23(8):1230-47doi: 10.1080/02643290600893594.
Barbeau, E. J., Didic, M., Felician, O., Tramoni, E., Guedj, E., Ceccaldi, M., & Poncet, M. (2006). Pure progressive amnesia: An atypical amnestic syndrome?. Cognitive neuropsychology, 23(8), 1230-47. https://doi.org/10.1080/02643290600893594
Barbeau, Emmanuel J, et al. "Pure progressive amnesia: An atypical amnestic syndrome?." Cognitive neuropsychology vol. 23,8 (2006): 1230-47. doi: https://doi.org/10.1080/02643290600893594
Barbeau EJ, Didic M, Felician O, Tramoni E, Guedj E, Ceccaldi M, Poncet M. Pure progressive amnesia: An atypical amnestic syndrome?. Cogn Neuropsychol. 2006 Dec 01;23(8):1230-47. doi: 10.1080/02643290600893594. PMID: 21049376.
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Cogn Neuropsychol. 2006 Dec 01;23(8):1230-47. doi: 10.1080/02643290600893594.

Pure progressive amnesia: An atypical amnestic syndrome?.

Cognitive neuropsychology

Emmanuel J Barbeau, Mira Didic, Olivier Felician, Eve Tramoni, Eric Guedj, Mathieu Ceccaldi, Michel Poncet

Affiliations

  1. Laboratoire de Neurophysiologie et Neuropsychologie, INSERM EMI-U 9926, Faculte de Medecine, Universite de la Mediterranee and Service de Neurologie et Neuropsychologie, Marseille, France.

PMID: 21049376 DOI: 10.1080/02643290600893594

Abstract

We report on M.S., an 83-year-old patient with isolated pure progressive amnesia. This rare, recently identified, form of amnesia has been described in elderly patients. Neuropathological studies suggest that this syndrome is an atypical clinical presentation of Alzheimer's disease. The aim of our study was to characterize the neuropsychological pattern of pure progressive amnesia in comparison with other amnestic syndromes and memory dissociations reported in the literature. Our results indicate that pure progressive amnesia is characterized by a highly unusual dissociation in the realm of memory, with severe deficits on tests based on recognition and recall of verbal and visual single items, contrasting with relatively preserved anterograde autobiographical and spatial memory and normal recall of complex material such as stories. These findings suggest that memory for single items could depend on an independent system. One hypothesis is that M.S.'s unusual memory profile results from relative dysfunction of the ventral medial temporal lobe pathway. An alternative explanation implicates cognitive reserve. Further studies are required in order to progress on this matter. In any case, pure progressive amnesia is a clinical syndrome that may provide further insight into the organization of declarative memory.

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