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Michaelides AP, Liakos CI, Antoniades C, et al. ST-Segment Depression in Hyperventilation Indicates a False Positive Exercise Test in Patients with Mitral Valve Prolapse. Cardiol Res Pract. 2010;2010:541781doi: 10.4061/2010/541781.
Michaelides, A. P., Liakos, C. I., Antoniades, C., Tsiachris, D. L., Soulis, D., Dilaveris, P. E., Tsioufis, K. P., & Stefanadis, C. I. (2010). ST-Segment Depression in Hyperventilation Indicates a False Positive Exercise Test in Patients with Mitral Valve Prolapse. Cardiology research and practice, 2010541781. https://doi.org/10.4061/2010/541781
Michaelides, Andreas P, et al. "ST-Segment Depression in Hyperventilation Indicates a False Positive Exercise Test in Patients with Mitral Valve Prolapse." Cardiology research and practice vol. 2010 (2010): 541781. doi: https://doi.org/10.4061/2010/541781
Michaelides AP, Liakos CI, Antoniades C, Tsiachris DL, Soulis D, Dilaveris PE, Tsioufis KP, Stefanadis CI. ST-Segment Depression in Hyperventilation Indicates a False Positive Exercise Test in Patients with Mitral Valve Prolapse. Cardiol Res Pract. 2010 Nov 14;2010:541781. doi: 10.4061/2010/541781. PMID: 21113438; PMCID: PMC2990857.
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Cardiol Res Pract. 2010 Nov 14;2010:541781. doi: 10.4061/2010/541781.

ST-Segment Depression in Hyperventilation Indicates a False Positive Exercise Test in Patients with Mitral Valve Prolapse.

Cardiology research and practice

Andreas P Michaelides, Charalampos I Liakos, Charalambos Antoniades, Dimitrios L Tsiachris, Dimitrios Soulis, Polichronis E Dilaveris, Konstantinos P Tsioufis, Christodoulos I Stefanadis

Affiliations

  1. Exercise Laboratory, 1st University Department of Cardiology, Athens Medical School, Hippokration Hospital, 15772 Athens, Greece.

PMID: 21113438 PMCID: PMC2990857 DOI: 10.4061/2010/541781

Abstract

Objectives. Mitral valve prolapse (MVP) is a known cause for false positive exercise test (ET). The purpose of this study was to establish additional electrocardiographic criteria to distinguish the false positive exercise results in patients with MVP. Methods. We studied 218 consecutive patients (53 ± 6 years, 103 males) with MVP (according to echocardiographic study), and positive treadmill ET was performed due to multiple cardiovascular risk factors or angina-like symptoms. A coronary angiography was performed to detect coronary artery disease (CAD). Results. From 218 patients, 90 (group A) presented with normal coronary arteries according to the angiography (false positive ET) while the rest 128 (group B) presented with CAD. ST-segment depression in hyperventilation phase was present in 54 patients of group A (60%) while only in 14 patients of group B (11%), P < .05. Conclusions. Presence of ST-segment depression in hyperventilation phase favors a false positive ET in patients with MVP.

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