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Dix L, Roth-Kleiner M, Osterheld MC. Placental vascular obstructive lesions: risk factor for developing necrotizing enterocolitis. Patholog Res Int. 2010;2010:838917doi: 10.4061/2010/838917.
Dix, L., Roth-Kleiner, M., & Osterheld, M. C. (2010). Placental vascular obstructive lesions: risk factor for developing necrotizing enterocolitis. Pathology research international, 2010838917. https://doi.org/10.4061/2010/838917
Dix, Laure, et al. "Placental vascular obstructive lesions: risk factor for developing necrotizing enterocolitis." Pathology research international vol. 2010 (2010): 838917. doi: https://doi.org/10.4061/2010/838917
Dix L, Roth-Kleiner M, Osterheld MC. Placental vascular obstructive lesions: risk factor for developing necrotizing enterocolitis. Patholog Res Int. 2010 May 10;2010:838917. doi: 10.4061/2010/838917. PMID: 21151528; PMCID: PMC2989861.
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Patholog Res Int. 2010 May 10;2010:838917. doi: 10.4061/2010/838917.

Placental vascular obstructive lesions: risk factor for developing necrotizing enterocolitis.

Pathology research international

Laure Dix, Matthias Roth-Kleiner, Maria-Chiara Osterheld

Affiliations

  1. Institute of Pathology, University of Lausanne, CH-1011 Lausanne, Switzerland.

PMID: 21151528 PMCID: PMC2989861 DOI: 10.4061/2010/838917

Abstract

Necrotizing enterocolitis (NEC) is a severe neonatal disease affecting particularly preterm infants. Its exact pathogenesis still remains unknown. In this study, we have compared the prevalence of vascular obstructive lesions in placentae of premature newborns which developed NEC and of a control group. We further compared separately the findings of placentae of infants of less than 30 weeks of gestation, the age group in which NEC occurs most frequently. We found signs of fetal vascular obstructive lesions in 65% of the placentae of preterm patients developing NEC, compared to only 17% of the placentae of preterm patients in the control group. In the age groups below 30 weeks of gestation, 58.5% of placentae of later NEC patients presented such lesions compared to 24.5% in the control group. The significant difference between NEC and control group suggests a strong association between fetal vascular obstructive lesions and NEC. Therefore, we propose that fetal vascular obstructive lesions might be considered as a risk factor for the development of NEC in premature infants.

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