Display options
Cite
Del Valle-Mojica LM, Cordero-Hernández JM, González-Medina G, et al. Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors. Evid Based Complement Alternat Med. 2010;2011:891819doi: 10.1155/2011/891819.
Del Valle-Mojica, L. M., Cordero-Hernández, J. M., González-Medina, G., Ramos-Vélez, I., Berríos-Cartagena, N., Torres-Hernández, B. A., & Ortíz, J. G. (2011). Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors. Evidence-based complementary and alternative medicine : eCAM, 2011891819. https://doi.org/10.1155/2011/891819
Del Valle-Mojica, Lisa M, et al. "Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors." Evidence-based complementary and alternative medicine : eCAM vol. 2011 (2011): 891819. doi: https://doi.org/10.1155/2011/891819
Del Valle-Mojica LM, Cordero-Hernández JM, González-Medina G, Ramos-Vélez I, Berríos-Cartagena N, Torres-Hernández BA, Ortíz JG. Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors. Evid Based Complement Alternat Med. 2011;2011:891819. doi: 10.1155/2011/891819. Epub 2010 Dec 02. PMID: 21151614; PMCID: PMC2997533.
Copy Download .nbib Format: NLM
Share it on

Evid Based Complement Alternat Med. 2011;2011:891819. doi: 10.1155/2011/891819. Epub 2010 Dec 02.

Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors.

Evidence-based complementary and alternative medicine : eCAM

Lisa M Del Valle-Mojica, José M Cordero-Hernández, Giselle González-Medina, Igmeris Ramos-Vélez, Nairimer Berríos-Cartagena, Bianca A Torres-Hernández, José G Ortíz

Affiliations

  1. Department of Pharmacology and Toxicology, School of Medicine, University of Puerto Rico, Medical Sciences Campus, P.O. Box 365067, San Juan, 00936-5067 Puerto Rico, USA.

PMID: 21151614 PMCID: PMC2997533 DOI: 10.1155/2011/891819

Abstract

The effects of two valerian extracts (aqueous and hydroalcoholic) were investigated through [(3)H]Glutamate ([(3)H]Glu) and [(3)H]Fluorowillardine ([(3)H]FW) receptor binding assays using rat synaptic membranes in presence of different receptor ligands. In addition, the extract stability was monitored spectrophotometrically. Both extracts demonstrated interaction with ionotropic glutamate receptors (iGluRs). However, the extracts displayed considerable differences in receptor selectivity. The hydroalcoholic extract selectively interacted with quisqualic acid (QA), group I metabotropic glutamate receptor (mGluR) ligand, while the aqueous extract did not alter the binding of QA. The stability of the extracts was examined during several weeks. Freshly prepared extract inhibited 38-60% of [(3)H]FW binding (AMPA). After 10 days, the aqueous extract inhibited 85% of [(3)H]FW binding while the hydroalcoholic extract markedly potentiated (200%) [(3)H]FW binding to AMPA receptors. Thus, our results showed that factors such as extraction solvent and extract stability determine the selectivity for glutamate receptor (GluR) interactions.

References

  1. Arzneimittelforschung. 1995 Jul;45(7):753-5 - PubMed
  2. Stress. 2003 Sep;6(3):189-97 - PubMed
  3. Planta Med. 1994 Jun;60(3):278-9 - PubMed
  4. Pharmacol Biochem Behav. 2004 Feb;77(2):399-404 - PubMed
  5. J AOAC Int. 2006 Jan-Feb;89(1):8-15 - PubMed
  6. Planta Med. 1985 Feb;(1):28-31 - PubMed
  7. Neurochem Res. 1999 Nov;24(11):1373-8 - PubMed
  8. Pharmacol Ther. 2007 Jul;115(1):116-47 - PubMed
  9. J Pharmacol Exp Ther. 2000 Dec;295(3):1267-75 - PubMed
  10. Pharmacol Biochem Behav. 1989 Apr;32(4):1065-6 - PubMed
  11. Biochem Pharmacol. 2005 Apr 1;69(7):1101-11 - PubMed
  12. Neuropharmacology. 2009 Jan;56(1):174-81 - PubMed
  13. J Ethnopharmacol. 2007 Jun 13;112(2):361-7 - PubMed
  14. Fitoterapia. 2000 Feb;71(1):19-24 - PubMed
  15. Pharmacol Biochem Behav. 2003 Jun;75(3):537-45 - PubMed
  16. Arch Int Pharmacodyn Ther. 1994 Mar-Apr;327(2):220-31 - PubMed
  17. Anal Biochem. 1976 May 7;72:248-54 - PubMed
  18. Nat Rev Drug Discov. 2005 Feb;4(2):131-44 - PubMed
  19. Phytother Res. 2004 Oct;18(10):831-6 - PubMed
  20. Curr Opin Investig Drugs. 2001 Aug;2(8):1112-9 - PubMed
  21. Phytomedicine. 2008 Jan;15(1-2):2-15 - PubMed
  22. Pharmacol Biochem Behav. 1982 Jul;17(1):65-71 - PubMed
  23. Planta Med. 2002 Oct;68(10):934-6 - PubMed
  24. J Pharm Pharmacol. 2009 Feb;61(2):251-6 - PubMed
  25. Anesth Analg. 2004 Feb;98(2):353-358 - PubMed
  26. Planta Med. 1985 Apr;(2):144-8 - PubMed
  27. Planta Med. 2008 Sep;74(11):1338-44 - PubMed
  28. Phytother Res. 2006 Sep;20(9):794-8 - PubMed
  29. J Pharm Pharmacol. 1999 May;51(5):505-12 - PubMed
  30. Am J Med. 2006 Dec;119(12):1005-12 - PubMed
  31. Neurotox Res. 2004;6(2):131-40 - PubMed
  32. Phytother Res. 2004 Apr;18(4):290-6 - PubMed
  33. Phytother Res. 2002 Nov;16(7):650-4 - PubMed
  34. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD004515 - PubMed
  35. Sleep Med. 2000 Apr 1;1(2):91-99 - PubMed
  36. Arzneimittelforschung. 1993 Jun;43(6):638-41 - PubMed
  37. J Nat Prod. 2002 Oct;65(10):1479-85 - PubMed

Publication Types

Grant support