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Luna M, Guzmán G, Navarro L, et al. Circadian rhythm of type II 5'deiodinase activity in the rat hypothalamic-pituitary-adrenal axis. Endocrine. 1995;3(8):597-601doi: 10.1007/BF02953025.
Luna, M., Guzmán, G., Navarro, L., de la Peña, S. S., & Valverde-R, C. (1995). Circadian rhythm of type II 5'deiodinase activity in the rat hypothalamic-pituitary-adrenal axis. Endocrine, 3(8), 597-601. https://doi.org/10.1007/BF02953025
Luna, M, et al. "Circadian rhythm of type II 5'deiodinase activity in the rat hypothalamic-pituitary-adrenal axis." Endocrine vol. 3,8 (1995): 597-601. doi: https://doi.org/10.1007/BF02953025
Luna M, Guzmán G, Navarro L, de la Peña SS, Valverde-R C. Circadian rhythm of type II 5'deiodinase activity in the rat hypothalamic-pituitary-adrenal axis. Endocrine. 1995 Aug;3(8):597-601. doi: 10.1007/BF02953025. PMID: 21153138.
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Endocrine. 1995 Aug;3(8):597-601. doi: 10.1007/BF02953025.

Circadian rhythm of type II 5'deiodinase activity in the rat hypothalamic-pituitary-adrenal axis.

Endocrine

M Luna, G Guzmán, L Navarro, S S de la Peña, C Valverde-R

Affiliations

  1. Centro de Neurobiología, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, México, D F.

PMID: 21153138 DOI: 10.1007/BF02953025

Abstract

Type II 5' deiodinase (5'D-II) activity was assessed in the hypothalamus (HP), pituitary (PIT), and adrenal gland (AG) of adult male rats after two different photoperiodic regimes: (1) cyclic light-dark conditions (LD, 12∶12) or (2) 4 days in continuous darkness (DD). Under cyclic LD conditions HP, PIT and AG 5'D-11 activity showed a significant circadian rhythm (P<0.004-<0.0001). The acrophases obtained by cosinor analysis were: HP, 12∶37; PIT, 03∶04 and AG, 02∶30 h. In contrast, after 4 days in DD, HP 5'D-II rhythmicity was abolished and there was a significant shift in the acrophase of both PIT and AG enzyme activity. These results suggest that the 5'D-II oscillation in PIT and AG corresponds to an endogenous circadian rhythm and is not only a response to the presence of a L/D cycle.

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