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Jih MH, Wu TC. Alterations in plasma and ovarian immunoreactive inhibin during reproductive aging in the female rat. Endocrine. 1995;3(5):327-33doi: 10.1007/BF03021415.
Jih, M. H., & Wu, T. C. (1995). Alterations in plasma and ovarian immunoreactive inhibin during reproductive aging in the female rat. Endocrine, 3(5), 327-33. https://doi.org/10.1007/BF03021415
Jih, M H, and Wu, T C. "Alterations in plasma and ovarian immunoreactive inhibin during reproductive aging in the female rat." Endocrine vol. 3,5 (1995): 327-33. doi: https://doi.org/10.1007/BF03021415
Jih MH, Wu TC. Alterations in plasma and ovarian immunoreactive inhibin during reproductive aging in the female rat. Endocrine. 1995 May;3(5):327-33. doi: 10.1007/BF03021415. PMID: 21153184.
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Endocrine. 1995 May;3(5):327-33. doi: 10.1007/BF03021415.

Alterations in plasma and ovarian immunoreactive inhibin during reproductive aging in the female rat.

Endocrine

M H Jih, T C Wu

Affiliations

  1. Department of Obstetrics & Gynecology, UCLA School of Medicine, 90024, Los Angeles, California, USA.

PMID: 21153184 DOI: 10.1007/BF03021415

Abstract

Previously, we showed that ovarian inhibin α- and β;(A)-subunit mRNAs are elevated in middle-aged and old persistent-estrous (PE) female rats. To determine whether higher inhibin subunit mRNA expressions result in increased circulating inhibins during reproductive aging, plasma immunoreactive inhibin α (ir-inh α) and gonadotropins were measured in young, middle-aged and PE rats. Plasma LH profiles were distinctly divergent in the middle-aged rats with some showing LH surges indistinguishable from young rats and others showing significantly attenuated LH surges. Plasma ir-inh α in middle-aged rats with LH surges were similar to those of young rats. However, animals with attenuated LH surges had higher peak ir-inh α levels than young and middle-aged animals with LH surges. Immunohistochemistry revealed increased levels of ovarian inhibin α staining in those animals with attenuated LH surges. Overall, the highest plasma and ovarian inhibin α were found in PE rats which lack LH surges. However, significant decreases of plasma and ovarian inhibin α were seen after reinstatement of estrous cyclicity with progesterone implant treatment. Thus, increases in both plasma and ovarian inhibin α appear to be closely associated with attenuation or loss of the preovulatory gonadotropin surge that occurs during aging.

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