Display options
Cite
Zoeller RT, Simonyi A, Butnariu O, et al. Effects of acute ethanol administration and cold exposure on the hypothalamic-pituitary-thyroid axis. Endocrine. 1995;3(1):39-47doi: 10.1007/BF02917447.
Zoeller, R. T., Simonyi, A., Butnariu, O., Fletcher, D. L., Rudeen, P. K., McCrone, S., & Petersen, S. L. (1995). Effects of acute ethanol administration and cold exposure on the hypothalamic-pituitary-thyroid axis. Endocrine, 3(1), 39-47. https://doi.org/10.1007/BF02917447
Zoeller, R T, et al. "Effects of acute ethanol administration and cold exposure on the hypothalamic-pituitary-thyroid axis." Endocrine vol. 3,1 (1995): 39-47. doi: https://doi.org/10.1007/BF02917447
Zoeller RT, Simonyi A, Butnariu O, Fletcher DL, Rudeen PK, McCrone S, Petersen SL. Effects of acute ethanol administration and cold exposure on the hypothalamic-pituitary-thyroid axis. Endocrine. 1995 Jan;3(1):39-47. doi: 10.1007/BF02917447. PMID: 21153235.
Copy Download .nbib Format: NLM
Share it on

Endocrine. 1995 Jan;3(1):39-47. doi: 10.1007/BF02917447.

Effects of acute ethanol administration and cold exposure on the hypothalamic-pituitary-thyroid axis.

Endocrine

R T Zoeller, A Simonyi, O Butnariu, D L Fletcher, P K Rudeen, S McCrone, S L Petersen

Affiliations

  1. Neuroscience and Behavior Program and Department of Biology, University of Massachusetts, Morrill Science Center, 01003, Amherst, Massachusetts, U.S.A..

PMID: 21153235 DOI: 10.1007/BF02917447

Abstract

A single dose of ethanol increases cellular levels of the mRNA encoding thyrotropin-releasing hormone (TRH) in neurons of the paraventricular nucleus (PVN), but blocks the cold-induced increase in the levels of this mRNA. Because the thyrotropic response to cold is dependent upon TRH secretion, we hypothesized that ethanol uncouples the stimulus-induced regulation of TRH secretion from the stimulus-induced regulation of TRH expression. We employed two complementary strategies to test this hypothesis. The first was to determine whether ethanol alters pituitary sensitivity to TRH. Animals given a single intraperitoneal injection of ethanol (3 g/kg) that produced a blood alcohol concentration of nearly 300 mg/100 mL exhibited the same increase in circulating levels of TSH following an intravenous infusion of TRH. Thus, ethanol does not appear to alter pituitary sensitivity to TRH. Second, we tested whether ethanol blocks the cold induction of c-fos expression in TRH neurons of the PVN. Both cold exposure and ethanol induced the expression of c-fos in the PVN and in TRH neurons; the effects of cold and ethanol on c-fos expression were additive. Thus, ethanol clearly does not block the cold activation of TRH neurons.

References

  1. Neuroendocrinology. 1991 Nov;54(5):477-81 - PubMed
  2. Oncogene. 1987;2(1):79-84 - PubMed
  3. J Neurochem. 1992 Oct;59(4):1309-15 - PubMed
  4. Endocrinology. 1977 Oct;101(4):1023-33 - PubMed
  5. Annu Rev Neurosci. 1991;14:421-51 - PubMed
  6. Neuroendocrinology. 1993 Jul;58(1):140-5 - PubMed
  7. Histochemistry. 1987;88(1):1-10 - PubMed
  8. Endocrinology. 1984 Feb;114(2):352-8 - PubMed
  9. Mol Endocrinol. 1987 Jun;1(6):408-12 - PubMed
  10. Science. 1987 Oct 2;238(4823):78-80 - PubMed
  11. Neurosci Lett. 1989 May 22;100(1-3):169-74 - PubMed
  12. Nucleic Acids Res. 1983 Mar 25;11(6):1759-71 - PubMed
  13. Life Sci. 1984 Oct 1;35(14):1439-44 - PubMed
  14. J Biol Chem. 1988 Nov 15;263(32):16604-9 - PubMed
  15. Neurosci Lett. 1990 Dec 11;120(2):271-4 - PubMed
  16. Endocrinology. 1987 Jun;120(6):2279-88 - PubMed
  17. J Endocrinol. 1987 Sep;114(3):443-8 - PubMed
  18. Brain Res Mol Brain Res. 1992 May;13(4):321-30 - PubMed
  19. Science. 1986 Jan 10;231(4734):159-61 - PubMed
  20. Brain Res Mol Brain Res. 1994 Jul;24(1-4):185-91 - PubMed
  21. Neurosci Lett. 1988 Feb 15;85(1):24-8 - PubMed
  22. Annu Rev Neurosci. 1990;13:111-27 - PubMed
  23. Endocrinology. 1991 Dec;129(6):3208-16 - PubMed
  24. Eur J Pharmacol. 1979 Jun;56(1-2):153-7 - PubMed
  25. Neuroendocrinology. 1983 Sep;37(3):225-8 - PubMed
  26. Endocrinology. 1977 Feb;100(2):496-505 - PubMed
  27. Proc Natl Acad Sci U S A. 1987 Oct;84(20):7329-33 - PubMed
  28. Cell Mol Neurobiol. 1987 Dec;7(4):353-66 - PubMed
  29. Neuroendocrinology. 1986;42(2):102-8 - PubMed
  30. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3720-4 - PubMed
  31. Mol Endocrinol. 1990 Aug;4(8):1087-94 - PubMed
  32. Endocrinology. 1982 May;110(5):1526-8 - PubMed
  33. Science. 1988 Jun 3;240(4857):1328-31 - PubMed
  34. Annu Rev Neurosci. 1993;16:17-29 - PubMed
  35. J Biol Chem. 1986 Sep 25;261(27):12675-9 - PubMed
  36. Endocrinology. 1988 Jul;123(1):523-7 - PubMed
  37. Neuroendocrinology. 1988 May;47(5):384-8 - PubMed
  38. Endocrinology. 1990 Dec;127(6):2955-62 - PubMed
  39. Neuroendocrinology. 1989 Nov;50(5):560-3 - PubMed
  40. Biochem Biophys Res Commun. 1988 Feb 29;151(1):615-22 - PubMed
  41. J Neuroendocrinol. 1994 Feb;6(1):19-23 - PubMed
  42. Endocrinology. 1987 Aug;121(2):619-24 - PubMed
  43. Cell. 1988 Nov 4;55(3):395-7 - PubMed
  44. Endocrinology. 1989 Aug;125(2):971-5 - PubMed
  45. Endocrinology. 1981 Nov;109(5):1731-8 - PubMed
  46. Endocrinology. 1977 Mar;100(3):738-44 - PubMed

Publication Types