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Lee JH, Chung WB, Kang JH, et al. A case of chloroquine-induced cardiomyopathy that presented as sick sinus syndrome. Korean Circ J. 2010;40(11):604-8doi: 10.4070/kcj.2010.40.11.604.
Lee, J. H., Chung, W. B., Kang, J. H., Kim, H. W., Kim, J. J., Kim, J. H., Hwang, H. J., Lee, J. B., Chung, J. W., Kim, H. L., Choi, Y. S., Park, C. S., Youn, H. J., & Lee, M. Y. (2010). A case of chloroquine-induced cardiomyopathy that presented as sick sinus syndrome. Korean circulation journal, 40(11), 604-8. https://doi.org/10.4070/kcj.2010.40.11.604
Lee, Jae Hak, et al. "A case of chloroquine-induced cardiomyopathy that presented as sick sinus syndrome." Korean circulation journal vol. 40,11 (2010): 604-8. doi: https://doi.org/10.4070/kcj.2010.40.11.604
Lee JH, Chung WB, Kang JH, Kim HW, Kim JJ, Kim JH, Hwang HJ, Lee JB, Chung JW, Kim HL, Choi YS, Park CS, Youn HJ, Lee MY. A case of chloroquine-induced cardiomyopathy that presented as sick sinus syndrome. Korean Circ J. 2010 Nov;40(11):604-8. doi: 10.4070/kcj.2010.40.11.604. Epub 2010 Nov 30. PMID: 21217940; PMCID: PMC3008834.
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Korean Circ J. 2010 Nov;40(11):604-8. doi: 10.4070/kcj.2010.40.11.604. Epub 2010 Nov 30.

A case of chloroquine-induced cardiomyopathy that presented as sick sinus syndrome.

Korean circulation journal

Jae Hak Lee, Woo-Baek Chung, Ju Hyun Kang, Hyung Woo Kim, Jin Jin Kim, Ji Hyun Kim, Hui-Jeong Hwang, Jea Beom Lee, Jong Won Chung, Hyo Lim Kim, Yun Seok Choi, Chul Soo Park, Ho-Joong Youn, Man Young Lee

Affiliations

  1. Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

PMID: 21217940 PMCID: PMC3008834 DOI: 10.4070/kcj.2010.40.11.604

Abstract

A 52-year-old woman with rheumatoid arthritis who had been treated with prednisone and hydroxychloroquine for >12 years presented with chest discomfort and a seizure. She was diagnosed with restrictive cardiomyopathy combined with sick sinus syndrome. A myocardial muscle biopsy was performed to identify the underlying cardiomyopathy, which showed marked muscle fiber hypertrophy, fiber dropout, slightly increased interstitial fibrous connective tissue, and extensive cytoplasmic vacuolization of the myocytes under light microscopy. Electron microscopy of the myocytes demonstrated dense, myeloid, and curvilinear bodies. The diagnosis of hydroxychloroquine-induced cardiomyopathy was made based on the clinical, hemodynamic, and pathologic findings. This is the first case report describing chloroquine-induced cardiomyopathy involving the heart conduction system.

Keywords: Cardiomyopathy, restrictive; Hydroxychloroquine; Sick sinus syndrome

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