Can Fam Physician. 1991 Jan;37:120-4.

Polypharmacy in the Elderly: Drug reactions and interaction in the aged.

Canadian family physician Medecin de famille canadien

H D Sanders

PMID: 21234085 PMCID: PMC2145157

Abstract

The elderly tolerate smaller doses of most drugs, largely because changes in body fat content, water content, and muscle mass often lead to higher blood levels than in a young person of the same weight. Moreover, diminished renal blood flow and creatinine clearance decrease excretion of agents cleared by the kidney. This leads to an increased number of drug reactions and interactions and consequent hospital admissions.

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