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Hishida A, Matsuo K, Goto Y, et al. Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions. World J Gastrointest Oncol. 2010;2(10):369-79doi: 10.4251/wjgo.v2.i10.369.
Hishida, A., Matsuo, K., Goto, Y., & Hamajima, N. (2010). Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions. World journal of gastrointestinal oncology, 2(10), 369-79. https://doi.org/10.4251/wjgo.v2.i10.369
Hishida, Asahi, et al. "Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions." World journal of gastrointestinal oncology vol. 2,10 (2010): 369-79. doi: https://doi.org/10.4251/wjgo.v2.i10.369
Hishida A, Matsuo K, Goto Y, Hamajima N. Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions. World J Gastrointest Oncol. 2010 Oct 15;2(10):369-79. doi: 10.4251/wjgo.v2.i10.369. PMID: 21160888; PMCID: PMC2999673.
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World J Gastrointest Oncol. 2010 Oct 15;2(10):369-79. doi: 10.4251/wjgo.v2.i10.369.

Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions.

World journal of gastrointestinal oncology

Asahi Hishida, Keitaro Matsuo, Yasuyuki Goto, Nobuyuki Hamajima

Affiliations

  1. Asahi Hishida, Yasuyuki Goto, Nobuyuki Hamajima, Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

PMID: 21160888 PMCID: PMC2999673 DOI: 10.4251/wjgo.v2.i10.369

Abstract

Gastric cancer is the most common malignancy of the gastrointestinal tract in East Asian populations and the second most frequent cause of cancer-related mortality in the world. While previous studies have investigated the genetic factors involved in gastric carcinogenesis, there still exist relatively few studies that have investigated the genetic traits associated with the risk of gastric precancerous conditions. In this paper we will review the biology and genetic polymorphisms involved in the genesis of gastric precancerous conditions reported to date and discuss the future prospects of this field of study. The associations of gastric precancerous conditions with polymorphisms in the cytotoxin-associated gene A-related genes (e.g. PTPN11 G/A at intron 3, rs2301756), those in the genes involved in host immunity against Helicobacter pylori (H. pylori) infection (e.g. TLR4 +3725G/C, rs11536889) or polymorphisms of the genes essential for the development/ differentiation of the gastric epithelial cells (e.g. RUNX3 T/A polymorphism at intron 3, rs760805) have been reported to date. Genetic epidemiological studies of the associations between H. pylori-induced gastric precancerous conditions and other gene polymorphisms in these pathways as well as polymorphisms of the genes involved in other pathways like oxidative DNA damage repair pathways would provide useful evidence for the individualized prevention of these H. pylori-induced gastric precancerous conditions.

Keywords: Gastric cancer; Gastric precancerous conditions; Genetic predisposition to disease; Helicobacter pylori; Single nucleotide polymorphisms

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