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Beyazit Y, Purnak T, Guven GS, et al. Local bone marrow Renin-Angiotensin system and atherosclerosis. Cardiol Res Pract. 2010;2011:714515doi: 10.4061/2011/714515.
Beyazit, Y., Purnak, T., Guven, G. S., & Haznedaroglu, I. C. (2010). Local bone marrow Renin-Angiotensin system and atherosclerosis. Cardiology research and practice, 2011714515. https://doi.org/10.4061/2011/714515
Beyazit, Yavuz, et al. "Local bone marrow Renin-Angiotensin system and atherosclerosis." Cardiology research and practice vol. 2011 (2010): 714515. doi: https://doi.org/10.4061/2011/714515
Beyazit Y, Purnak T, Guven GS, Haznedaroglu IC. Local bone marrow Renin-Angiotensin system and atherosclerosis. Cardiol Res Pract. 2010 Dec 22;2011:714515. doi: 10.4061/2011/714515. PMID: 21234405; PMCID: PMC3014698.
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Cardiol Res Pract. 2010 Dec 22;2011:714515. doi: 10.4061/2011/714515.

Local bone marrow Renin-Angiotensin system and atherosclerosis.

Cardiology research and practice

Yavuz Beyazit, Tugrul Purnak, Gulay Sain Guven, Ibrahim C Haznedaroglu

Affiliations

  1. Department of Gastroenterology, Turkiye Yuksek Ihtisas Teaching and Research Hospital, 06100 Ankara, Turkey.

PMID: 21234405 PMCID: PMC3014698 DOI: 10.4061/2011/714515

Abstract

Local hematopoietic bone marrow (BM) renin-angiotensin system (RAS) affects the growth, production, proliferation differentiation, and function of hematopoietic cells. Angiotensin II (Ang II), the dominant effector peptide of the RAS, regulates cellular growth in a wide variety of tissues in pathobiological states. RAS, especially Ang II and Ang II type 1 receptor (AT1R), has considerable proinflammatory and proatherogenic effects on the vessel wall, causing progression of atherosclerosis. Recent investigations, by analyzing several BM chimeric mice whose BM cells were positive or negative for AT1R, disclosed that AT1R in BM cells participates in the pathogenesis of atherosclerosis. Therefore, AT1R blocking not only in vascular cells but also in the BM could be an important therapeutic approach to prevent atherosclerosis. The aim of this paper is to review the function of local BM RAS in the pathogenesis of atherosclerosis.

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