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Carrion AF, Czul F, Arosemena LR, et al. Propylthiouracil-induced acute liver failure: role of liver transplantation. Int J Endocrinol. 2010;2010:910636doi: 10.1155/2010/910636.
Carrion, A. F., Czul, F., Arosemena, L. R., Selvaggi, G., Garcia, M. T., Tekin, A., Tzakis, A. G., Martin, P., & Ghanta, R. K. (2010). Propylthiouracil-induced acute liver failure: role of liver transplantation. International journal of endocrinology, 2010910636. https://doi.org/10.1155/2010/910636
Carrion, Andres F, et al. "Propylthiouracil-induced acute liver failure: role of liver transplantation." International journal of endocrinology vol. 2010 (2010): 910636. doi: https://doi.org/10.1155/2010/910636
Carrion AF, Czul F, Arosemena LR, Selvaggi G, Garcia MT, Tekin A, Tzakis AG, Martin P, Ghanta RK. Propylthiouracil-induced acute liver failure: role of liver transplantation. Int J Endocrinol. 2010;2010:910636. doi: 10.1155/2010/910636. Epub 2010 Dec 23. PMID: 21234410; PMCID: PMC3014703.
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Int J Endocrinol. 2010;2010:910636. doi: 10.1155/2010/910636. Epub 2010 Dec 23.

Propylthiouracil-induced acute liver failure: role of liver transplantation.

International journal of endocrinology

Andres F Carrion, Frank Czul, Leopoldo R Arosemena, Gennaro Selvaggi, Monica T Garcia, Akin Tekin, Andreas G Tzakis, Paul Martin, Ravi K Ghanta

Affiliations

  1. Department of Medicine, University of Miami Leonard M. Miller School of Medicine, 185 SW 7th Street, Unit 1510, Miami, FL 33130, USA.

PMID: 21234410 PMCID: PMC3014703 DOI: 10.1155/2010/910636

Abstract

Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the clinical presentation, histological characteristics, and posttransplant management are described as well as alternative therapeutic options. Frequent monitoring for PTU-induced hepatic dysfunction is strongly advised because timely discontinuation of this drug and implementation of noninvasive therapeutic interventions may prevent progression to liver failure or even death.

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