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Al-Janabi AA. Elevation of antidermatophytic action of mefenamic acid by cobalt ions. Indian J Pharmacol. 2010;42(6):351-3doi: 10.4103/0253-7613.71907.
Al-Janabi, A. A. (2010). Elevation of antidermatophytic action of mefenamic acid by cobalt ions. Indian journal of pharmacology, 42(6), 351-3. https://doi.org/10.4103/0253-7613.71907
Al-Janabi, Ali Abdul Hussein S. "Elevation of antidermatophytic action of mefenamic acid by cobalt ions." Indian journal of pharmacology vol. 42,6 (2010): 351-3. doi: https://doi.org/10.4103/0253-7613.71907
Al-Janabi AA. Elevation of antidermatophytic action of mefenamic acid by cobalt ions. Indian J Pharmacol. 2010 Dec;42(6):351-3. doi: 10.4103/0253-7613.71907. PMID: 21189903; PMCID: PMC2991690.
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Indian J Pharmacol. 2010 Dec;42(6):351-3. doi: 10.4103/0253-7613.71907.

Elevation of antidermatophytic action of mefenamic acid by cobalt ions.

Indian journal of pharmacology

Ali Abdul Hussein S Al-Janabi

Affiliations

  1. Department of Clinical Laboratory, College of Applicable of Medical Sciences, University of Karbala, Karbala, Iran.

PMID: 21189903 PMCID: PMC2991690 DOI: 10.4103/0253-7613.71907

Abstract

OBJECTIVES: To evaluate the antifungal property of mefenamic acid, which is a member of non-steroidal anti-inflammatory drugs (NSAIDs) group.

MATERIALS AND METHODS: In order to evaluate the antifungal property of mefenamic acid on dermatophytes, it was mixed with cobalt (Co) in culture media. Two species related to two genera of dermatophytes were tested for their susceptibility to mefenamic acid and its complex with Co by using colony diameter measurement method.

RESULTS: The inhibitory action of mefenamic acid on fungal strains was increased in the presence of Co. Epidermophyton floccosum showed more susceptibly to either mefenamic acid or its complex with Co than Trichophyton mentagrophytes variant mentagrophytes.

CONCLUSIONS: Mefenamic acid showed potential ability to prevent growth of dermatophytes. This ability increased due to the presence of Co.

Keywords: Cobalt; dermatophytes; mefenamic acid

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