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Lange LG, Schreiner GF. Immune cytokines and cardiac disease. Trends Cardiovasc Med. 1992;2(4):145-51doi: 10.1016/1050-1738(92)90022-K.
Lange, L. G., & Schreiner, G. F. (1992). Immune cytokines and cardiac disease. Trends in cardiovascular medicine, 2(4), 145-51. https://doi.org/10.1016/1050-1738(92)90022-K
Lange, L G, and Schreiner, G F. "Immune cytokines and cardiac disease." Trends in cardiovascular medicine vol. 2,4 (1992): 145-51. doi: https://doi.org/10.1016/1050-1738(92)90022-K
Lange LG, Schreiner GF. Immune cytokines and cardiac disease. Trends Cardiovasc Med. 1992 Jul-Aug;2(4):145-51. doi: 10.1016/1050-1738(92)90022-K. PMID: 21239261.
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Trends Cardiovasc Med. 1992 Jul-Aug;2(4):145-51. doi: 10.1016/1050-1738(92)90022-K.

Immune cytokines and cardiac disease.

Trends in cardiovascular medicine

L G Lange, G F Schreiner

Affiliations

  1. Department of Medicine, Cardiology Division, Jewish Hospital of St. Louis at the Washington University Medical Center, St. Louis, MO 63110, USA.

PMID: 21239261 DOI: 10.1016/1050-1738(92)90022-K

Abstract

In conditions such as idiopathic dilated congestive cardiomyopathy associated with lymphocytic myocarditis and cardiac allograft rejection, the immune system can reversibly impair cardiac function. Cytokines interleukin-1 and tumor necrosis factor disrupt β-adrenergic signal transduction and agonist stimulation of contractility. Identification of this reversible effect potentially offers a novel pathophysiologic mechanism for producing cardiac injury.

Copyright © 1992. Published by Elsevier Inc.

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