Display options
Cite
Kullberg J, Sundbom M, Haenni A, et al. Gastric bypass promotes more lipid mobilization than a similar weight loss induced by low-calorie diet. J Obes. 2010;2011:959601doi: 10.1155/2011/959601.
Kullberg, J., Sundbom, M., Haenni, A., Freden, S., Johansson, L., Börnert, P., Ahlström, A., Ahlström, H., & Karlsson, A. (2011). Gastric bypass promotes more lipid mobilization than a similar weight loss induced by low-calorie diet. Journal of obesity, 2011959601. https://doi.org/10.1155/2011/959601
Kullberg, Joel, et al. "Gastric bypass promotes more lipid mobilization than a similar weight loss induced by low-calorie diet." Journal of obesity vol. 2011 (2011): 959601. doi: https://doi.org/10.1155/2011/959601
Kullberg J, Sundbom M, Haenni A, Freden S, Johansson L, Börnert P, Ahlström A, Ahlström H, Karlsson A. Gastric bypass promotes more lipid mobilization than a similar weight loss induced by low-calorie diet. J Obes. 2011;2011:959601. doi: 10.1155/2011/959601. Epub 2010 Dec 21. PMID: 21197152; PMCID: PMC3010702.
Copy Download .nbib Format: NLM
Share it on

J Obes. 2011;2011:959601. doi: 10.1155/2011/959601. Epub 2010 Dec 21.

Gastric bypass promotes more lipid mobilization than a similar weight loss induced by low-calorie diet.

Journal of obesity

Joel Kullberg, Magnus Sundbom, Arvo Haenni, Susanne Freden, Lars Johansson, Peter Börnert, Anders Ahlström, Håkan Ahlström, Anders Karlsson

Affiliations

  1. Department of Radiology, Uppsala University, 751 85 Uppsala, Sweden.

PMID: 21197152 PMCID: PMC3010702 DOI: 10.1155/2011/959601

Abstract

Background. Recently, we found large reductions in visceral and subcutaneous fat one month after gastric bypass (GBP), without any change in liver fat content. Purpose. Firstly to characterize weight loss-induced lipid mobilization after one month with preoperative low-calorie diet (LCD) and a subsequent month following GBP, and secondly, to discuss the observations with reference to our previous published findings after GBP intervention alone. Methods. 15 morbidly obese women were studied prior to LCD, at GBP, and one month after GBP. Effects on metabolism were measured by magnetic resonance techniques and blood tests. Results. Body weight was similarly reduced after both months (mean: -8.0 kg, n = 13). Relative body fat changes were smaller after LCD than after GBP (-7.1 ± 3.6% versus -10 ± 3.2%, P = .029, n = 13). Liver fat fell during the LCD month (-41%, P = .001, n = 13) but was unaltered one month after GBP (+12%). Conclusion. Gastric bypass seems to cause a greater lipid mobilization than a comparable LCD-induced weight loss. One may speculate that GBP-altered gastrointestinal signalling sensitizes adipose tissue to lipolysis, promoting the changes observed.

References

  1. J Clin Endocrinol Metab. 2006 May;91(5):1735-40 - PubMed
  2. MAGMA. 2001 May;12(2-3):141-52 - PubMed
  3. Eur J Clin Nutr. 2002 Jun;56(6):551-6 - PubMed
  4. Magn Reson Med. 2010 Jun;63(6):1659-68 - PubMed
  5. Obes Surg. 2005 Nov-Dec;15(10):1396-402 - PubMed
  6. Br J Surg. 2006 Feb;93(2):210-5 - PubMed
  7. Obes Rev. 2001 Feb;2(1):3-14 - PubMed
  8. J Clin Endocrinol Metab. 2007 Dec;92(12):4678-85 - PubMed
  9. Br J Surg. 2004 Apr;91(4):418-23 - PubMed
  10. Metab Syndr Relat Disord. 2010 Feb;8(1):15-20 - PubMed
  11. Int J Obes (Lond). 2008 Nov;32(11):1640-6 - PubMed
  12. Diabetologia. 1985 Jul;28(7):412-9 - PubMed
  13. J Clin Endocrinol Metab. 1995 Apr;80(4):1407-15 - PubMed
  14. Surg Obes Relat Dis. 2007 Mar-Apr;3(2):141-5; discussion 145-6 - PubMed
  15. Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E906-16 - PubMed
  16. J Neurosci. 2009 May 6;29(18):5916-25 - PubMed
  17. Diabetes Care. 2007 May;30(5):1075-80 - PubMed
  18. Ann Med. 2005;37(5):347-56 - PubMed
  19. J Clin Invest. 1976 Apr;57(4):875-84 - PubMed
  20. J Clin Gastroenterol. 1987 Apr;9(2):204-7 - PubMed
  21. J Magn Reson Imaging. 2009 Jul;30(1):185-93 - PubMed
  22. Am J Med. 2003 Nov;115(7):554-9 - PubMed
  23. Am J Clin Nutr. 2008 May;87(5):1141-7 - PubMed
  24. J Clin Endocrinol Metab. 2008 Jul;93(7):2479-85 - PubMed
  25. J Magn Reson. 1997 Nov;129(1):35-43 - PubMed
  26. Diabetes. 2008 Dec;57(12):3199-204 - PubMed
  27. Obes Surg. 2005 Apr;15(4):462-73 - PubMed
  28. Eur J Endocrinol. 2006 Jan;154(1):53-9 - PubMed
  29. Obes Surg. 2008 Oct;18(10):1297-304 - PubMed
  30. Int J Clin Pract. 2009 Sep;63(9):1285-300 - PubMed
  31. Scand J Clin Lab Invest. 1970 Mar;25(2):171-9 - PubMed
  32. Obes Surg. 2007 May;17(5):608-16 - PubMed
  33. Annu Rev Med. 2010;61:393-411 - PubMed
  34. J Clin Endocrinol Metab. 2003 Jul;88(7):3177-83 - PubMed

Publication Types