Display options
Cite
Bid HK, Houghton PJ. Targeting angiogenesis in childhood sarcomas. Sarcoma. 2010;2011:601514doi: 10.1155/2011/601514.
Bid, H. K., & Houghton, P. J. (2011). Targeting angiogenesis in childhood sarcomas. Sarcoma, 2011601514. https://doi.org/10.1155/2011/601514
Bid, Hemant K, and Houghton, Peter J. "Targeting angiogenesis in childhood sarcomas." Sarcoma vol. 2011 (2011): 601514. doi: https://doi.org/10.1155/2011/601514
Bid HK, Houghton PJ. Targeting angiogenesis in childhood sarcomas. Sarcoma. 2011;2011:601514. doi: 10.1155/2011/601514. Epub 2010 Dec 09. PMID: 21197468; PMCID: PMC3005857.
Copy Download .nbib Format: NLM
Share it on

Sarcoma. 2011;2011:601514. doi: 10.1155/2011/601514. Epub 2010 Dec 09.

Targeting angiogenesis in childhood sarcomas.

Sarcoma

Hemant K Bid, Peter J Houghton

Affiliations

  1. Center for Childhood Cancer, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.

PMID: 21197468 PMCID: PMC3005857 DOI: 10.1155/2011/601514

Abstract

Angiogenesis and vasculogenesis constitute two processes in the formation of new blood vessels and are essential for progression of solid tumors. Consequently, targeting angiogenesis, and to a lesser extent vasculogenesis, has become a major focus in cancer drug development. Angiogenesis inhibitors are now being tested in pediatric populations whereas inhibitors of vasculogenesis are in an earlier stage of development. Despite the initial enthusiasm for targeting angiogenesis for treatment of cancer, clinical trials have shown only incremental increases in survival, and agents have been largely cytostatic rather than inducing tumor regressions. Consequently, the role of such therapeutic approaches in the context of curative intent for childhood sarcomas is less clear. Here we review the literature on blood vessel formation in sarcomas with a focus on pediatric sarcomas and developments in targeting angiogenesis for treatment of these rare cancers.

References

  1. Pediatr Blood Cancer. 2008 Jun;50(6):1190-7 - PubMed
  2. Pediatr Blood Cancer. 2008 Mar;50(3):581-7 - PubMed
  3. Int J Cancer. 2008 Aug 15;123(4):831-7 - PubMed
  4. Pediatr Blood Cancer. 2008 Apr;50(4):799-805 - PubMed
  5. N Engl J Med. 2003 Jul 31;349(5):427-34 - PubMed
  6. Cancer. 1996 Jul 15;78(2):345-9 - PubMed
  7. J Surg Oncol. 1998 Sep;69(1):21-7 - PubMed
  8. Eur J Cancer. 2003 Jul;39(11):1511-6 - PubMed
  9. Clin Cancer Res. 2007 Jul 1;13(13):3942-50 - PubMed
  10. Annu Rev Cell Dev Biol. 1995;11:73-91 - PubMed
  11. Science. 2002 Dec 6;298(5600):1912-34 - PubMed
  12. Ann Oncol. 2008 Apr;19(4):807-13 - PubMed
  13. Gynecol Oncol. 2003 Dec;91(3):513-7 - PubMed
  14. Br J Cancer. 1962 Jun;16:306-22 - PubMed
  15. Cancer Res. 2003 Jan 15;63(2):364-74 - PubMed
  16. Mol Cancer Ther. 2007 May;6(5):1620-8 - PubMed
  17. Angiogenesis. 2001;4(4):259-62 - PubMed
  18. Acta Paediatr Suppl. 1999 Feb;88(428):37-45 - PubMed
  19. Curr Opin Oncol. 2001 Jul;13(4):261-9 - PubMed
  20. Cancer Res. 1994 Nov 1;54(21):5531-4 - PubMed
  21. Nat Med. 2000 Apr;6(4):389-95 - PubMed
  22. Hum Pathol. 2000 Dec;31(12):1448-54 - PubMed
  23. Curr Opin Drug Discov Devel. 2008 Mar;11(2):178-85 - PubMed
  24. Clin Cancer Res. 1999 Nov;5(11):3516-22 - PubMed
  25. Ann Surg Oncol. 1998 Jan-Feb;5(1):48-53 - PubMed
  26. Kidney Int. 2010 Sep;78(6):561-8 - PubMed
  27. J Clin Invest. 1990 Dec;86(6):1806-14 - PubMed
  28. Biochim Biophys Acta. 2006 Aug;1766(1):1-22 - PubMed
  29. Cancer Res. 2009 Oct 1;69(19):7662-71 - PubMed
  30. Proc Natl Acad Sci U S A. 1986 Oct;83(19):7297-301 - PubMed
  31. J Clin Oncol. 1995 Feb;13(2):477-81 - PubMed
  32. J Clin Oncol. 2007 Jul 20;25(21):3045-54 - PubMed
  33. Biochemistry (Mosc). 2003 Mar;68(3):286-300 - PubMed
  34. Int J Cancer. 2006 Sep 1;119(5):1039-46 - PubMed
  35. Am J Clin Pathol. 1994 Feb;101(2):198-203 - PubMed
  36. Oncogene. 2007 Mar 15;26(12):1811-9 - PubMed
  37. Int J Cancer. 1996 Jun 21;69(3):205-11 - PubMed
  38. Drug Resist Updat. 1998 Mar;1(1):59-61 - PubMed
  39. Cancer J Sci Am. 1995 May-Jun;1(1):43-8 - PubMed
  40. Br J Cancer. 1995 Nov;72(5):1224-9 - PubMed
  41. Cancer Cell. 2007 Jan;11(1):83-95 - PubMed
  42. Science. 2005 Jan 7;307(5706):58-62 - PubMed
  43. Oncologist. 2008 Jun;13(6):668-78 - PubMed
  44. Nat Rev Cancer. 2004 Aug;4(8):579-91 - PubMed
  45. Int J Cancer. 2004 Apr 20;109(4):507-15 - PubMed
  46. Cancer Res. 1996 Oct 15;56(20):4570-4 - PubMed
  47. Int J Oncol. 2003 Aug;23(2):269-84 - PubMed
  48. Cancer Res. 1994 May 15;54(10):2803-7 - PubMed
  49. Mol Cell. 2003 Jun;11(6):1491-501 - PubMed
  50. Pharmacotherapy. 2007 Aug;27(8):1125-44 - PubMed
  51. Oncologist. 2009 Aug;14(8):800-5 - PubMed
  52. Nat Med. 2002 Feb;8(2):128-35 - PubMed
  53. Nat Clin Pract Oncol. 2006 Aug;3(8):448-57 - PubMed
  54. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12718-23 - PubMed
  55. Pediatr Blood Cancer. 2010 Jul 15;55(1):67-75 - PubMed
  56. Future Oncol. 2009 May;5(4):421-32 - PubMed
  57. FASEB J. 2004 Sep;18(12):1456-8 - PubMed
  58. Pediatr Blood Cancer. 2008 Jul;51(1):42-8 - PubMed
  59. Ann Surg Oncol. 2001 Jan-Feb;8(1):72-9 - PubMed
  60. Pediatr Blood Cancer. 2010 Dec 1;55(6):1126-33 - PubMed
  61. Cancer Res. 1996 May 1;56(9):1983-7 - PubMed
  62. Mol Cell Endocrinol. 1998 Apr 30;139(1-2):1-6 - PubMed
  63. Mol Cancer Ther. 2010 Feb;9(2):410-8 - PubMed
  64. Int J Cancer. 2006 Aug 15;119(4):839-46 - PubMed
  65. Int J Cancer. 2001 Dec 1;94(5):645-51 - PubMed
  66. Int J Cancer. 2000 Jan 1;85(1):40-5 - PubMed
  67. Br J Cancer. 2001 Jun 15;84(12):1610-5 - PubMed
  68. Circ Res. 1999 Apr 16;84(7):785-96 - PubMed
  69. Adv Cancer Res. 1992;59:115-65 - PubMed
  70. Clin Cancer Res. 2000 Feb;6(2):572-7 - PubMed
  71. Int J Cancer. 1995 May 29;61(5):732-7 - PubMed
  72. Oncogene. 2005 Dec 1;24(54):8025-37 - PubMed
  73. J Clin Oncol. 2002 Nov 1;20(21):4368-80 - PubMed
  74. Cancer Res. 2005 May 15;65(10):4389-400 - PubMed
  75. Nature. 1997 Apr 17;386(6626):671-4 - PubMed
  76. J Clin Oncol. 2007 Mar 10;25(8):1003-8 - PubMed
  77. Cancer Cell. 2006 Mar;9(3):153-5 - PubMed
  78. Cancer Res. 1994 Feb 15;54(4):903-7 - PubMed
  79. Cell Cycle. 2006 Sep;5(18):2049-53 - PubMed
  80. Curr Oncol Rep. 2006 Jul;8(4):310-5 - PubMed
  81. Mol Cancer Ther. 2006 Jan;5(1):114-20 - PubMed
  82. Crit Rev Oncol Hematol. 2006 Jul;59(1):40-50 - PubMed
  83. Oncogene. 2002 May 16;21(22):3552-61 - PubMed
  84. Carcinogenesis. 2008 Nov;29(11):2106-11 - PubMed
  85. Semin Diagn Pathol. 2008 Nov;25(4):304-16 - PubMed
  86. J Pediatr Surg. 1995 Jul;30(7):1038-41 - PubMed
  87. Cancer Res. 2005 Jul 1;65(13):5864-71 - PubMed
  88. J Clin Oncol. 2006 Mar 1;24(7):1145-51 - PubMed
  89. Nat Rev Drug Discov. 2004 May;3(5):391-400 - PubMed
  90. J Clin Oncol. 2005 Feb 1;23(4):792-9 - PubMed
  91. FASEB J. 2002 Jun;16(8):771-80 - PubMed
  92. Cell Growth Differ. 1990 Jul;1(7):325-31 - PubMed
  93. Oncol Rep. 1999 Sep-Oct;6(5):959-64 - PubMed
  94. Cancer. 1994 Oct 15;74(8):2245-50 - PubMed

Publication Types

Grant support