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Lu ZR, Wu X. Polydisulfide Based Biodegradable Macromolecular Magnetic Resonance Imaging Contrast Agents. Isr J Chem. 2010;50(2):220-232doi: 10.1002/ijch.201000016.
Lu, Z. R., & Wu, X. (2010). Polydisulfide Based Biodegradable Macromolecular Magnetic Resonance Imaging Contrast Agents. Israel journal of chemistry, 50(2), 220-232. https://doi.org/10.1002/ijch.201000016
Lu, Zheng-Rong, and Wu, Xueming. "Polydisulfide Based Biodegradable Macromolecular Magnetic Resonance Imaging Contrast Agents." Israel journal of chemistry vol. 50,2 (2010): 220-232. doi: https://doi.org/10.1002/ijch.201000016
Lu ZR, Wu X. Polydisulfide Based Biodegradable Macromolecular Magnetic Resonance Imaging Contrast Agents. Isr J Chem. 2010 Aug;50(2):220-232. doi: 10.1002/ijch.201000016. PMID: 21331318; PMCID: PMC3038583.
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Isr J Chem. 2010 Aug;50(2):220-232. doi: 10.1002/ijch.201000016.

Polydisulfide Based Biodegradable Macromolecular Magnetic Resonance Imaging Contrast Agents.

Israel journal of chemistry

Zheng-Rong Lu, Xueming Wu

Affiliations

  1. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.

PMID: 21331318 PMCID: PMC3038583 DOI: 10.1002/ijch.201000016

Abstract

Macromolecular Gd(III) complexes are advantageous over small molecular Gd(III) complexes in contrast enhanced magnetic resonance imaging (MRI) because of their prolonged blood circulation and preferential tumor accumulation. However, macromolecular contrast agents have not been approved for clinical applications because of the safety concerns related to their slow body excretion. Polydisulfide Gd(III) complexes have been designed and developed as biodegradable macromolecular MRI contrast agents to alleviate the concerns by facilitating the clearance of Gd(III) complexes from the body. These agents initially behave as macromolecular agents and result in superior contrast enhancement in the vasculature and tumor tissues. They can then be readily degraded in vivo into small molecular chelates that can rapidly excrete from the body via renal filtration after the MRI examinations. Various polydisulfide Gd(III) complexes have been prepared as biodegradable macromolecular MRI contrast agents. These agents have resulted in strong contrast enhancement in the vasculature and tumor tissue in animal models with minimal long-term tissue accumulation comparable to small molecular contrast agents. Polydisulfide Gd(III) complexes are promising for further clinical development as safe and effective biodegradable macromolecular MRI contrast agents for cardiovascular and cancer imaging. The review summarizes the chemistry and properties of polydisulfide Gd(III) complexes.

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