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Semenzato M, Cogliati S, Scorrano L. Prohibitin(g) cancer: aurilide and killing by Opa1-dependent cristae remodeling. Chem Biol. 2011;18(1):8-9doi: 10.1016/j.chembiol.2011.01.001.
Semenzato, M., Cogliati, S., & Scorrano, L. (2011). Prohibitin(g) cancer: aurilide and killing by Opa1-dependent cristae remodeling. Chemistry & biology, 18(1), 8-9. https://doi.org/10.1016/j.chembiol.2011.01.001
Semenzato, Martina, et al. "Prohibitin(g) cancer: aurilide and killing by Opa1-dependent cristae remodeling." Chemistry & biology vol. 18,1 (2011): 8-9. doi: https://doi.org/10.1016/j.chembiol.2011.01.001
Semenzato M, Cogliati S, Scorrano L. Prohibitin(g) cancer: aurilide and killing by Opa1-dependent cristae remodeling. Chem Biol. 2011 Jan 28;18(1):8-9. doi: 10.1016/j.chembiol.2011.01.001. PMID: 21276934.
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Chem Biol. 2011 Jan 28;18(1):8-9. doi: 10.1016/j.chembiol.2011.01.001.

Prohibitin(g) cancer: aurilide and killing by Opa1-dependent cristae remodeling.

Chemistry & biology

Martina Semenzato, Sara Cogliati, Luca Scorrano

Affiliations

  1. Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy.

PMID: 21276934 DOI: 10.1016/j.chembiol.2011.01.001

Abstract

Proapoptotic drugs targeting the mitochondrial Bcl-2 rheostat of apoptosis are tools to selectively kill cancer cells. Sato et al. (2011) expand the available toolkit by identifying the target of the cytotoxic natural product aurilide in the prohibitin Opa1-dependent apoptotic cristae remodeling.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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