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Palaniyandi SS, Qi X, Yogalingam G, et al. Regulation of mitochondrial processes: a target for heart failure. Drug Discov Today Dis Mech. 2010;7(2):e95-e102doi: 10.1016/j.ddmec.2010.07.002.
Palaniyandi, S. S., Qi, X., Yogalingam, G., Ferreira, J. C., & Mochly-Rosen, D. (2010). Regulation of mitochondrial processes: a target for heart failure. Drug discovery today. Disease mechanisms, 7(2), e95-e102. https://doi.org/10.1016/j.ddmec.2010.07.002
Palaniyandi, Suresh Selvaraj, et al. "Regulation of mitochondrial processes: a target for heart failure." Drug discovery today. Disease mechanisms vol. 7,2 (2010): e95-e102. doi: https://doi.org/10.1016/j.ddmec.2010.07.002
Palaniyandi SS, Qi X, Yogalingam G, Ferreira JC, Mochly-Rosen D. Regulation of mitochondrial processes: a target for heart failure. Drug Discov Today Dis Mech. 2010;7(2):e95-e102. doi: 10.1016/j.ddmec.2010.07.002. PMID: 21278905; PMCID: PMC3026286.
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Drug Discov Today Dis Mech. 2010;7(2):e95-e102. doi: 10.1016/j.ddmec.2010.07.002.

Regulation of mitochondrial processes: a target for heart failure.

Drug discovery today. Disease mechanisms

Suresh Selvaraj Palaniyandi, Xin Qi, Gouri Yogalingam, Julio Cesar Batista Ferreira, Daria Mochly-Rosen

Affiliations

  1. Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174.

PMID: 21278905 PMCID: PMC3026286 DOI: 10.1016/j.ddmec.2010.07.002

Abstract

Cardiac mitochondria, the main source of energy as well as free radicals, are vital organelles for normal functioning of the heart. Mitochondrial number, structure, turnover and function are regulated by processes such as mitochondrial protein quality control, mitochondrial fusion and fission and mitophagy. Recent studies suggest that abnormal changes in these mitochondrial regulatory processes may contribute to the pathology of heart failure (HF). Here we discuss these processes and their potential as therapeutic targets.

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