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Van Belle V, Decock J, Hendrickx W, et al. Short-Term Prognostic Index for Breast Cancer: NPI or Lpi. Patholog Res Int. 2010;2011:918408doi: 10.4061/2011/918408.
Van Belle, V., Decock, J., Hendrickx, W., Brouckaert, O., Pintens, S., Moerman, P., Wildiers, H., Paridaens, R., Christiaens, M. R., Van Huffel, S., & Neven, P. (2010). Short-Term Prognostic Index for Breast Cancer: NPI or Lpi. Pathology research international, 2011918408. https://doi.org/10.4061/2011/918408
Van Belle, V, et al. "Short-Term Prognostic Index for Breast Cancer: NPI or Lpi." Pathology research international vol. 2011 (2010): 918408. doi: https://doi.org/10.4061/2011/918408
Van Belle V, Decock J, Hendrickx W, Brouckaert O, Pintens S, Moerman P, Wildiers H, Paridaens R, Christiaens MR, Van Huffel S, Neven P. Short-Term Prognostic Index for Breast Cancer: NPI or Lpi. Patholog Res Int. 2010 Dec 28;2011:918408. doi: 10.4061/2011/918408. PMID: 21253502; PMCID: PMC3021876.
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Patholog Res Int. 2010 Dec 28;2011:918408. doi: 10.4061/2011/918408.

Short-Term Prognostic Index for Breast Cancer: NPI or Lpi.

Pathology research international

V Van Belle, J Decock, W Hendrickx, O Brouckaert, S Pintens, P Moerman, H Wildiers, R Paridaens, M R Christiaens, S Van Huffel, P Neven

Affiliations

  1. Division SCD, Department of Electrical Engineering (ESAT), K.U.Leuven, Kasteelpark Arenberg 10/2446, 3000 Leuven, Belgium.

PMID: 21253502 PMCID: PMC3021876 DOI: 10.4061/2011/918408

Abstract

Axillary lymph node involvement is an important prognostic factor for breast cancer survival but is confounded by the number of nodes examined. We compare the performance of the log odds prognostic index (Lpi), using a ratio of the positive versus negative lymph nodes, with the Nottingham Prognostic Index (NPI) for short-term breast cancer specific disease free survival. A total of 1818 operable breast cancer patients treated in the University Hospital of Leuven between 2000 and 2005 were included. The performance of the NPI and Lpi were compared on two levels: calibration and discrimination. The latter was evaluated using the concordance index (cindex), the number of patients in the extreme groups, and difference in event rates between these. The NPI had a significant higher cindex, but a significant lower percentage of patients in the extreme risk groups. After updating both indices, no significant differences between NPI and Lpi were noted.

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