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Methods Mol Med. 2001;52:77-103. doi: 10.1385/1-59259-073-X:77.

8 determination of plasma homocysteine.

Methods in molecular medicine

R Accinni, O Parodi

Affiliations

  1. Clinical Physiology Institute of CNR, Section of Milan, Department of Cardiology A. De Gasperis, Ospedale Niguarda Cà Granda, Milan, Italy.

PMID: 21340933 DOI: 10.1385/1-59259-073-X:77

Abstract

INTRODUCTION: A number of epidemiological and clinical studies have linked elevated plasma homocysteine (Hcy) to atherosclerotic vascular disease affecting coronary, carotid, and peripheral vessels. Plasma Hcy can be considered a marker of methionine metabolic efficiency, mainly affected by dietary intake of vitamins, especially folate, vitamin B(6), and B(12), as well as by genetic mutations of key metabolic enzymes and renal elimination.

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